中老年抑郁症患者低动力症状与甲状腺激素的关系

Relationship between Fatigue and Thyroid Hormone Levels in Middle-Aged and Elderly Patients with Depression

目的:探讨中老年抑郁症患者低动力症状与甲状腺激素水平的关系。方法:中老年抑郁症患者,根据有无低动力症状分为低动力组(n=68例)、非低动力组(n=54例),另外将在本院体检的65例健康志愿者作为对照组(n=65例)。收集抑郁症患者的年龄、首发、自杀行为等一般情况,并抽取3组的空腹血标本检测血清FT3、FT4、TSH水平进行比较和分析。结果:低动力组FT3较非低动力组及对照组明显下降,差异均有统计学意义(P<0.05);低动力组FT4/FT3较非低动力组及对照组明显升高,差异均有统计学意义(P<0.05)。低动力组中,中年和老年患者甲状腺激素水平差异均无统计学意义(P>0.05)。结论:伴有低动力症状的中老年抑郁症患者甲状腺激素水平存在异常,可能与疾病状态有关。

Objective:To investigate the relationship between fatigue and thyroid hormone levels in middle-aged and elderly patients with depression.Methods:Total 122 cases of middle-aged and elderly patients with depression were enrolled and divided according to the presence or absence of fatigue symptoms into the fatigue group(n=68)and non-fatigue group(n=54).In addition,65 healthy volunteers who underwent physical examination at our hospital served as the control group(n=65).The age,first episode,suicidal behavior,and other general conditions of the patients were collected,and fasting blood samples of the three groups were taken to detect serum FT3,FT4,and TSH levels for comparison and analysis.Results:FT3 in the fatigue group was significantly lower than that in the non-fatigue group and control group(P<0.05).FT4/FT3 in the fatigue group was significantly higher than that in the non-fatigue group and control group(P<0.05).There was no difference in thyroid hormone levels between middle-aged and elderly patients in the fatigue group(P>0.05).Conclusion:There is an abnormality in thyroid hormone levels in middle-aged and elderly patients with depression who present fatigue symptoms,and this abnormality may be related to the disease state.