低分子肝素联合华法林治疗急性肺栓塞患者的疗效及安全性评价

Efficacy and safety of low molecular weight heparin combined with warfarin in the treatment of patients with acute pulmonary embolism

目的探讨低分子肝素联合华法林治疗急性肺栓塞患者的疗效及安全性。方法选择104例急性肺栓塞患者作为研究对象,根据患者入院先后顺序将其均分为观察组与对照组。对照组患者采用皮下注射低分子肝素治疗,观察组患者采用低分子肝素联合华法林治疗,治疗后对2组的临床疗效及治疗安全性进行综合评价。结果治疗后,观察组动脉血氧分压、动脉血二氧化碳分压及血氧饱和度均显著优于对照组(P<0.05);治疗后,观察组患者肺动脉压及呼吸困难评分均显著优于对照组(P<0.05);观察组患者治疗总有效率为92.3%,显著高于对照组的76.9%(P<0.05);2组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论低分子肝素联合华法林治疗急性肺栓塞的临床疗效较好,对于改善患者临床症状、血流动力指标以及肺功能具有重要意义,且不良反应发生率较低。

Objective To explore the efficacy and safety of low molecular weight heparin combined with warfarin in the treatment of patients with acute pulmonary embolism.Methods Totally 104 patients with acute pulmonary embolism were selected and equally divided into observation group and control group according to the order of hospital admission.Patients in the control group were treated with hypodermic injection of low molecular weight heparin,and patients in the observation group were treated with low molecular weight heparin and warfarin.After treatment,the clinical efficacy and therapeutic safety were comprehensively evaluated in both groups.Results After treatment,the levels of arterial partial pressure of oxygen,arterial partial pressure of carbon dioxide and blood oxygen saturation in the observation group were significantly better than those in the control group(P<0.05).After treatment,the pulmonary artery pressure and dyspnea score in the observation group were significantly better than those in the control group(P<0.05).The total effective rate of the observation group was 92.3%,which was significantly higher than 76.9%in the control group(P<0.05).There was no significant difference in total incidence of adverse reactions between the two groups(P>0.05).Conclusion Low molecular weight heparin combined with warfarin shows a good clinical effect in the treatment of patients with acute pulmonary embolism,which is of great significance in improving the clinical symptoms,hemodynamic indexes and pulmonary function of patients,and has lower incidence of adverse reactions.