摘要
目的探讨盐酸伐昔洛韦颗粒剂联合口腔炎喷雾剂治疗儿童疱疹性口炎的疗效及安全性。方法选择150例疱疹性口炎患儿作为研究对象,按密封信封法随机分为对照A组、对照B组与实验组,各50例。对照A组采用盐酸伐昔洛韦颗粒剂治疗,对照B组采用口腔炎喷雾剂治疗,实验组采用盐酸伐昔洛韦颗粒剂联合口腔炎喷雾剂治疗,均治疗1周。比较3组的治疗效果、临床症状缓解时间(疱疹消退时间、体温恢复时间、康复时间)、血清炎症因子[白细胞介素-10(IL-10)、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)]水平、生活质量[婴儿皮肤病生活质量量表(IDQOL)评分]以及安全性指标(血常规检查结果、不良反应)的变化情况。结果治疗后,实验组治疗效果显著优于对照A组、对照B组(P<0.05);实验组疱疹消退时间、体温恢复时间、康复时间显著短于对照A组、对照B组(P<0.05);治疗后,3组IL-10水平较治疗前显著上升(P<0.05),IL-2、TNF-α水平较治疗前显著下降(P<0.05),且实验组较对照A组、对照B组变化更显著(P<0.05);治疗后,3组IDQOL评分均显著低于治疗前,且实验组评分显著低于对照A组、对照B组(P<0.05);3组血常规检查结果无显著差异(P>0.05),且均无明显不良反应发生。结论采用盐酸伐昔洛韦颗粒剂联合口腔炎喷雾剂治疗儿童疱疹性口炎疗效显著,可缩短临床症状缓解时间,改善血清炎症因子水平,提高生活质量,安全性较好。
Objective To explore the efficacy and safety of valaciclovir hydrochloride granules combined with stomatitis spray in the treatment of children with herpetic stomatitis.Methods A total of 150 children with herpetic stomatitis were selected and divided into control group A(n=50),control group B(n=50)and experimental group(n=50)according to the sealed envelope method.The control group A was treated with valaciclovir hydrochloride granules,the control group B was treaded with stomatitis spray,the experimental group was treated with valaciclovir hydrochloride granules and stomatitis spray,and all the children were treated for 1 week.The therapeutic effect,relief time of clinical symptoms(regression time of herpes,recovery time of body temperature,rehabilitation time),levels of serum inflammatory factors[interleukin-10(IL-10),interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)],quality of life[score of Infant Dermatology Quality of Life Index(IDQOL)]and safety indicators[result of blood test,adverse reactions]were compared among the three groups.Results After treatment,the therapeutic effect in the experimental group was significantly better than that in the control group A and control group B(P<0.05).The regression time of herpes,recovery time of body temperature and rehabilitation time in the experimental group were significantly shorter than those in the control group A and control group B(P<0.05).After treatment,the level of IL-10 increased significantly in the three groups,while levels of IL-2 and TNF-αdecreased significantly(P<0.05),and changes of levels of IL-10,IL-2 and TNF-αin the experimental group were significantly greater than those in the control group A and the control group B(P<0.05).The IDQOL score in the three groups significantly decreased after treatment,and was significantly lower in the experimental group than that in the control group A and the control group B(P<0.05).There was no significant difference in the result of blood test among the three groups,and no obvious adverse reactions were observed.Conclusion Valaciclovir hydrochloride granules combined with stomatitis spray is effective in the treatment of children with herpetic stomatitis,which can shorten the relief time of clinical symptoms,improve the levels of serum inflammatory factors and the quality of life,and has higher safety.
作者
张梦葩
高菲
董潇
曹代娣
金佳佳
王锐
ZHANG Mengpa;GAO Fei;DONG Xiao;CAO Daidi;JIN Jiajia;WANG Rui(Department of Stomatology,Xi′an Daxing Hospital,Xi′an,Shaanxi,710082)
出处
《实用临床医药杂志》
CAS
2020年第12期107-110,共4页
Journal of Clinical Medicine in Practice
基金
陕西省科技厅重点研发计划项目(2017SF-111)。