糖代谢异常对中老年人群腹部脂肪容积和分布的影响

Effects of abnormal glucose metabolism on the volume and distribution of abdominal fat in the middle-aged and elderly

目的探讨糖代谢异常对不同年龄段中老年人腹部脂肪容积和分布的影响。方法根据北京协和医院保健医疗部2015—2018年间184例体检者的腹部CT,计算其腹部脂肪容积与分布,分析糖代谢异常人群与正常人群在51~<80岁与≥80岁两年龄段间腹部脂肪容积与分布的不同。结果(1)无糖代谢异常人群中,与51~<80岁年龄组比较,≥80岁年龄组腹部内脏脂肪容积相对增多[(61.5±25.5)cm3与(79.5±37.8)cm3,t=0.979,P=0.338],腹部皮下脂肪容积相对减少[(88.9±33.5)cm3与(77.8±27.6)cm3,t=1.319,P=0.191],腹部脂肪总容积大致相同[(150.4±48.1)cm3与(148.3±59.2)cm3,t=0.157,P=0.875],各组间差异均无统计学意义,腹部内脏脂肪百分比增高[(40.7±11.0)%与(46.2±9.5)%,t=1.971,P=0.052]。(2)有糖代谢异常人群中,与51~<80岁年龄组比较,≥80岁年龄组腹部内脏脂肪容积明显减少[(76.2±27.6)cm3与(61.4±32.4)cm3,t=2.365,P=0.020],腹部皮下脂肪和腹部脂肪总容积相对减少(分别为腹部内脏脂肪容积[(84.1±36.7)cm3与(80.8±38.5)cm3,t=0.413,P=0.680;腹部脂肪总容积[(160.3±52.3)cm3与(142.2±63.2)cm3,t=1.509,P=0.134],但差异无统计学意义,腹部内脏脂肪百分比明显减少[(47.9±10.3)%与(42.3±10.9)%,t=2.480,P=0.015]。结论对于无糖代谢异常人群,随着年龄增加进入80岁及以上高龄以后腹部内脏脂肪有可能会逐渐增加,但对于有糖代谢异常人群进入80岁及以上高龄后腹部内脏脂肪将逐步减少。

Objective To explore the effects of abnormal glucose metabolism on the volume and distribution of abdominal fat in middle and old people of different ages.Methods Abdominal fat volume and distribution were calculated based on abdominal CT scans of 184 patients who underwent physical examination in the department of health care of Peking union medical college hospital from 2015 to 2018.To analyze the difference of abdominal fat volume and distribution between abnormal and normal people in glucose metabolism between 51~<80 years old.Result Among patients without glucose metabolic disorder,compared with the group 51~<80 years old,abdominal visceral fat volume in the group≥80 years old increased[(61.5±25.5)cm3 vs(79.5±37.8)cm3,t=0.979,P=0.338],while subcutaneous abdominal fat volume decreased[(88.9±33.5)cm3 vs(77.8±27.6)cm3,t=-1.319,P=0.191],and the total abdominal fat volume was roughly the same[(150.4±48.1)cm3 vs(148.3±59.2)cm3,t=0.157,P=0.875],there were no statistically significant difference between the groups,abdominal visceral fat percentage increased[(40.7±11.0)%vs(46.2±9.5)%,t=1.971,P=0.052].Among patients with glucose metabolic disorder,compared with the group 51~<80 years old,abdominal visceral fat volume in the group≥80 years old significantly decreased[(76.2±27.6)cm3 vs(61.4±32.4)cm3,t=-2.365,P=0.020],total abdominal subcutaneous fat volume and total abdominal fat volume decreased[(84.1±36.7)cm3 vs(80.8±38.5)cm3,t=-0.413,P=0.680,respectively)];total abdominal fat volume[(160.3±52.3)cm3 vs(142.2±63.2)cm3,t=-1.509,P=0.134],but there was no statistically significant difference,abdominal visceral fat percentage significantly reduced[(47.9±10.3)%vs(42.3±10.9)%,t=-2.480,P=0.015)].Conclusion For people without abnormal glucose metabolism,abdominal visceral fat may increase gradually after the age of 80 and above,but for people with abnormal glucose metabolism,abdominal visceral fat will decrease gradually after age 80 and above.