共生菌调控机体肺泡巨噬细胞抗肿瘤免疫应答的研究进展

Advance on commensal microbiota in regulating the anti-tumor immune response of alveolar macrophages

机体黏膜组织中存在着大量的“共生菌”,共生菌及其代谢产物不仅是机体维持免疫稳态所必需,并可影响机体对多种免疫介导性疾病的易感性。肺泡巨噬细胞是肺泡腔表面分布最为丰富的固有免疫细胞,在肺脏免疫应答及相关疾病发生发展中发挥重要作用。呼吸道及肠道菌群均可对肺泡巨噬细胞的表型及功能产生调控作用,共生菌缺失可以导致肺泡巨噬细胞的比例和数量发生变化,并影响肺泡巨噬细胞的功能和极化状态。长链非编码RNA是巨噬细胞免疫稳态和功能的重要调控分子,可以调控巨噬细胞的炎性反应及极化等,同时机体lncRNA的表达亦受共生菌信号的影响。

There are a lot of"commensal microbiota"in the mucosal tissues of the body.Commensal microbiota and their metabolites are not only necessary for the maintenance of immune homeostasis,but also can affect the susceptibility of the body to a variety of immune-mediated diseases.Alveolar macrophages are the most abundant innate immune cells on the surface of alveolar cavity,witch play an important role in the immune response of the lung and the occurrence and development of related diseases.Commensal microbiota of the respiratory and intestinal tract can regulate the phenotype and function of alveolar macrophages.The absence of commensal microbiota can lead to the decrease in the proportion and number of alveolar macrophages.Long non-coding RNA is an important regulatory molecule for the immune homeostasis and function of macrophages,which can regulate the inflammatory response and polarization of macrophages.Meanwhile,the expression of lncRNA is also affected by the signal of commensal bacteria.