摘要
Epigenetic modifications,including those on DNA and histones,have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic pathways.In turn,metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin modifications.Recently,non-enzymatic covalent modifications(NECMs)by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple mechanisms.Here,we summarize these recent advances in the identification and characterization of NECMs on nucleic acids,histones,and transcription factors,providing an additional mechanistic link between metabolism and epigenetics.
基金
Work in the David lab is supported by R21 DA044767,CCSG core grant P30 CA008748,and SPORE P50-CA192937 from the National Institutes of Health.In addition,work in the lab is supported by the Tri-institutional Therapeutic Discovery Institute,the Mr.William H.Goodwin and Mrs.Alice Goodwin and the Commonwealth Foundation for Cancer Research and the Center for Experimental Therapeutics at MSKCC,the Pershing Square Sohn Cancer Research Alliance,and Cycle for Survival.Y.D.is a Josie Robertson Young Investigator.Additionally,YD is supported by the Parker Institute for Cancer Immunotherapy and the Anna Fuller Cancer Research Foundation.
