血友病性关节超声评估量表评分与其临床功能评分的相关性研究

Correlation between ultrasonic evaluation score and clinical function score in hemophiliac arthropathy

目的探讨血友病性关节超声评估量表(HEAD-US-C)评分与其临床功能评分的相关性。方法采用HEAD-US-C评分对40例男性血友病患者的240个膝、肘、踝关节进行超声评分,并采用血友病性关节健康评估表(HJHS)2.1版及功能独立性评分表(FISH)对其关节临床功能情况进行评估。根据凝血因子缺乏的类型将40例血友病患者分为A型32例和B型8例,比较不同类型血友病患者HEAD-US-C评分、HJHS评分、FISH评分;分析HEAD-US-C评分与HJHS评分、FISH评分间的相关性。结果40例患者共240个关节,HEAD-US-C评分为22.50(8.00,30.50),HJHS评分为31.50(15.50,46.75),FISH评分为27.00(21.50,32.00)。不同类型血友病患者间的HEAD-US-C评分、HJHS评分、FISH评分比较差异均无统计学意义。40例血友病患者HEAD-US-C评分与HJHS评分呈正相关(r=0.884,P<0.001),与FISH评分呈负相关(r=-0.825,P<0.001)。结论HEAD-US-C评分与HJHS评分和FISH评分均有较好的相关性,可以客观评估血友病患者关节损伤情况,为临床提供参考信息。

Objective To explore the correlation between hemophilic early arthropathy detection with ultrasound in China(HEAD-US-C)score and the clinical function score in hemophiliacs joints.Methods A total of 240 knee,elbow and ankle joints of 40 male hemophilia patients were evaluated by HEAD-US-C score,the joints’function was evaluated by hemophilia joint health scores(HJHS)2.1 and the functional independence score for haemophilia(FISH).The correlation between HEAD-US-Cscore and HJHS score,FISH score were analyzed.According to the type of deficiency of coagulation factors,40 hemophilia patients were divided into type A(n=32)and type B(n=8),then they were to be analyzed whether there were differences among different types of hemophilia patients in HEAD-US-C score,HJHS score and FISH score.Results In the 240 joints of 40 patients,HEAD-US-C score was 22.50(8.00,30.50),HJHS score was 31.50(15.50,46.75),and FISH score was 27.00(21.50,32.00).There were no significant differences in different types of hemophilia patients in HEAD-US-C score,HJHS score and FISH score.There was a positive correlation between HEAD-US-C score and HJHS score(r=0.884,P<0.001),and a negative correlation between HEAD-US-C score and FISH score(r=-0.825,P<0.001)in 40 hemophilia patients.Conclusion HEAD-US-C score has a good correlation with HJHS score and FISH score,and ultrasound can provide more objective evaluation of joint injury.