血清相关指标联合检测对冠心病诊断及预后的评估价值

Value of combined measurement of serum-related parameters levels in diagnosis of CHD and assessment of its outcome

目的探讨血清N末端B型钠尿肽前体(NT-proBNP)、单核细胞趋化蛋白1(MCP-1)、TNF-α和不规则趋化因子(FKN)联合检测对冠心病诊断及预后的评估价值。方法选择冠心病患者70例为观察组,另选健康体检者70例为对照组。采用酶联免疫吸附法检测各组血清NT-proBNP、MCP-1、TNF-α和FKN水平,评价各项指标单独检测或联合检测对冠心病患者临床诊断的价值。结果与对照组比较,观察组血清NT-proBNP、MCP-1、TNF-α和FKN水平明显升高[(517.97±114.30)μg/L vs(62.38±15.77)μg/L,(120.07±20.14)μg/L vs(51.18±11.23)μg/L,(15.38±2.16)μg/L vs(5.42±2.14)μg/L,(75.26±4.83)μg/L vs(30.42±3.66)μg/L,P<0.01]。与单独检测血清NT-proBNP、MCP-1、TNF-α和FKN比较,4种血清标志物联合检测用于冠心病诊断的敏感性和准确性明显增高(92.63%vs 78.05%、74.49%、76.33%、75.86%,P=0.001;93.27%vs 80.05%、78.41%、78.67%、75.47%,P=0.000)。结论血清NT-proBNP、MCP-1、TNF-α和FKN联合检测可明确诊断,评估预后。

Objective To study the value of combined measurement of serum NT-proBNP,MCP-1,TNF-αand irregular chemokines levels in diagnosis of CHD and assessment of its outcome.Methods Seventy elderly CHD patients admitted to our hospital served as an observation group with 70 healthy elderly patients who underwent physical examination in our hospital served as a control group.The serum NT-proBNP,MCP-1,TNF-αand irregular chemokines levels in two groups were measured by ELISA and their value in clinical diagnosis of CHD was assessed.Results The serum levels of NT-proBNP,MCP-1,TNF-αand irregular chemokines were significantly higher in observation group than in control group(517.97±114.30μg/L vs 62.38±15.77μg/L,120.07±20.14μg/L vs 51.18±11.23μg/L,15.38±2.16μg/L vs 5.42±2.14μg/L,75.26±4.83μg/L vs 30.42±3.66μg/L,P<0.01).The sensitivity and accuracy of combined measurement of serum NT-proBNP,MCP-1,TNF-αand irregular chemokines levels in diagnosis of CHD were significantly higher than those of measuring each of them(92.63%vs 78.05%,74.49%,76.33%,75.86%,P=0.001;93.27%vs 80.05%,78.41%,78.67%,75.47%,P=0.000).Conclusion Combined measurement of serum NT-proBNP,MCP-1,TNF-αand irregular chemokines levels can improve the diagnosis of CHD and assessment of its outcome.