糖肽类抗生素的研究进展

Research Progress of Glycopeptide Antibiotics

糖肽类抗生素,尤其是万古霉素是临床治疗耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)等多重耐药的革兰阳性菌感染的有效药物。由于糖肽类抗生素耐药性问题愈加严重,寻找和开发新的化合物应用于临床治疗变得十分紧迫。本文就糖肽类抗生素的作用与耐药机制、新批准的糖肽类抗菌药物、化学修饰与新的筛选开发手段展开综述,以期对糖肽类抗生素药物的开发提供思路。

Glycopeptide antibiotics,especially vancomycin,are effective drugs for clinical treatment of multiple drug-resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus(MRSA).With the development of bacterial drug resistance,the problem of glycopeptide antibiotic resistance is becoming more and more serious,so it is very urgent to find and develop new compounds for clinical treatment.This paper reviews the action and resistance mechanism of glycopeptide antibiotics,newly approved glycopeptide antibiotics,chemical modification and new screening and development methods,in order to provide ideas for the development of glycopeptide antibiotics.