囊膜糖蛋白gE对α疱疹病毒毒力的影响

Effect of Alphaherpesvirus Glycoprotein gE on Virulence

近年来,α疱疹病毒的囊膜糖蛋白gE在病毒细胞间传递、神经系统入侵、免疫逃避等方面的研究取得新的进展。gE能促进合胞体形成,影响病毒的顺行、逆行神经传导,也是第一个报道可以抑制浆细胞样树突状细胞产生Ⅰ型干扰素的病毒蛋白。本文对α疱疹病毒囊膜糖蛋白gE与毒力之间的关系进行阐述,以期为α疱疹病毒gE的功能研究提供参考。

In recent years,new progress has been made in the research of glycoprotein gE of alphaherpesvirus in virus intercellular transmission,nervous system infection,and immune evasion.gE is involved in syncytium formation,anterograde and retrograde neurotransmission,and is also the first reported viral protein that inhibits the activation of plasmacytoid dendritic cells to produce type I interferon.This summary reviews the relationship between gE and virulence to provide useful information for the further study of gE.