牙周炎与慢性阻塞性肺疾病相关性的研究进展

Research progress of correlation between periodontitis and chronic obstructive pulmonary disease

牙周炎与全身疾病的关系已成为研究热点,其与慢性阻塞性肺疾病的相关性逐渐被重视。较多的流行病学调查证实了牙周炎影响患者肺功能,促进慢性阻塞性肺疾病症状的加重,因此牙周干预治疗减轻牙周症状,从而使减轻慢性阻塞性肺疾病患者的症状成为可能。本文进一步综述了两者之间的关联机制:牙周炎可以通过诱发系统性免疫反应加重肺部损伤;局部牙周致病菌单独或协同作用诱发肺部炎性因子水平的升高,免疫细胞的聚集促进肺上皮细胞的损伤。

The relationship between periodontitis and systemic diseases has become a research hotspot,and the correlation between periodontitis and chronic obstructive pulmonary disease has been paid more and more attention.More epidemiological investigations have confirmed that periodontitis affects the lung function of patients and promotes the aggravation of symptoms of chronic obstructive pulmonary disease.Therefore,it becomes possible that periodontal intervention can reduce periodontal symptoms,so as to reduce the symptoms of patients with chronic obstructive pulmonary disease.In this paper,the mechanism of the relationship between the two is further reviewed:periodontitis can aggravate lung injury by inducing systemic immune response;local periodontal pathogens alone or cooperatively induce the elevation of the level of pulmonary inflammatory cytokines and the accumulation of immune cells promotes the injury of lung epithelial cells.