临床药物个体化治疗技术进展与展望

Progress and Prospect of Individualized Clinical Medication Techniques

近年来,个体化治疗已成为提高临床药物治疗有效性和安全性的关键策略。随着药物检测技术的不断进步以及药物基因组学技术在临床的应用,临床药物个体化治疗模式正在逐渐转变,检测方法和检测的药物品种也在不断增多。根据国内外相关文献和资料,对应用于临床药物个体化治疗的治疗药物监测和基因检测技术的研究与应用进展进行总结,并归纳了有望应用于个体化治疗的新技术,同时提出了目前临床个体化治疗模式仍存在的一些瓶颈问题及未来的发展方向。

In recent years,individualized therapy has become a key strategy to improve the efficacy and safety of clinical drug therapy.With the continuous development of drug detection technology and clinical application of pharmacogenomics,individualized clinical medication is gradually changing,with more detection methods and varieties of drugs.Based on domestic and foreign literature and information,this article reviews the research and application progress on therapeutic drug monitoring and gene testing technology used in individualized medication,and summarizes the potential new technologies expected to be applied to individualized therapy in the future,and at the same time,raises some bottleneck problems in the current clinical individualized treatment for the reference of future research.