环状RNA在甲状腺乳头状癌中的研究进展

Research progress of circRNAs in thyroid papillary carcinoma

目的总结目前环状RNA(circRNAs)在甲状腺乳头状癌中的作用和未来研究的重点。方法复习circRNAs的生物学功能及其在甲状腺乳头状癌中作用及研究现状的文献,并做综述。结果 circRNAs在甲状腺乳头状癌组织中存在异常表达,并且其可以作为miRNA海绵或与RNA结合蛋白相互作用,从而调控与细胞增殖、凋亡、侵袭和转移相关的蛋白,影响甲状腺乳头状癌细胞的生物学特性。结论 circRNAs有望成为甲状腺乳头状癌早期诊断的生物标志物和治疗的分子靶点,这为甲状腺乳头状癌的防治提供了一种科学有效的方法。

Objective To summarize the role of circular RNA(circRNAs) in thyroid papillary carcinoma(PTC) and the emphasis of future research. Method Relevant literatures in recent years about the biological function of circRNA and its role in PTC were reviewed. Results circRNAs had abnormal expression in PTC tissues. Besides, by working as miRNA sponges or interacting with RNA-binding proteins, circRNAs regulated the expression of proteins that were associated with cell proliferation, apoptosis, invasion, and metastasis, which could affect the biological characteristics of tumor cells. Conclusion circRNAs are expected to be the biomarkers for early diagnosis of PTC or potential targets for PTC therapy and provid therapeutic bases to prevent PTC.