未来再生外科学:优化脱细胞和再细胞策略构建工程化肝脏

Future in regenerative surgical discipline:construction engineered liver with optimized strategy of decellularized and recellularized technology

终末期肝病严重威胁人类健康,肝移植是唯一有效治疗方案。然而,由于肝源短缺导致多数患者无法顺利度过等待移植过程。伴随生物组织工程技术的快速发展,"脱细胞和再细胞"等策略,已发展为目前构建重要生命器官(肝脏)的首选技术,这为治疗终末期肝病开辟了新思路。目前,研究者正致力于该项技术的优化,以达到最终成功构建可移植功能性"新肝脏"的目的。笔者就此技术及其优化策略在再生外科学领域中应用的可行性及面临的挑战进行综述。

End-stage liver disease(ESLD)is a serious threat to human health,and liver transplantation is the only effective treatment.However,most of the patients died in the process of waiting for transplantation due to the shortage of liver source.With the rapid development of biological tissue enginee-ring technology,researchers have established the strategy of'decellularized and recellularized technology’,which has deve-loped into the first choice for construction of important organs such as the liver and opened up new ideas for the treatment of ESLD.At present,scientists are working on the optimization of this technology,in order to construction a functional'new liver’for transplantation.The authors review the feasibility and challenges of the application of this technology and its optimization stra-tegy in the field of regenerative surgery.