抗N-甲基-D-天冬氨酸受体脑炎相关性癫痫的治疗研究进展

Advances in the treatment of epilepsy associated with N-methyl-D-aspartate receptor encephalitis

癫痫发作是抗NMDAR脑炎最常见的临床症状,也是患者入院治疗的常见原因。其发病机制是一种与自身免疫抗体相关的癫痫,单独使用抗癫痫药物往往效果不佳,而早期给予免疫治疗是决定癫痫预后良好的关键因素。抗癫痫药物可以作为治疗抗NMDAR脑炎相关性癫痫的辅助治疗手段。目前临床上没有针对抗NMDAR脑炎相关性癫痫治疗方案的明确指南,也缺乏高质量的相关治疗方案疗效的随机对照研究,因此本文对目前抗NMDAR脑炎相关性癫痫的治疗研究进展做一综述。

Seizure is the most common clinical symptom of anti N-methyl-D-aspartate receptor(NMDAR)encephalitis and also the common cause of hospitalization.Its pathogenesis is an epilepsy associated with autoimmune antibodies,and antiepileptic drugs alone are often not effective,while early administration of immunotherapy is a key factor in determining a good prognosis for epilepsy.Antiepileptic drugs can be used as an adjunct in the treatment of epilepsy associated with anti-NMDAR encephalitis.At present,there is no clear guideline for the treatment of anti-NMDAR encephalitis-associated epilepsy in clinical practice,and there is no high-quality randomized controlled study on the efficacy of relevant treatment options.Therefore,this article reviews the current research progress in the treatment of anti-NMDAR encephalitis-associated epilepsy.