烯醇硅醚经三氯甲基自由基加成串联消除反应合成β,β-二氯-α,β-不饱和酮

Synthesis ofβ,β-Dichloro-α,β-unsaturated Ketones by Trichloromethyl Radical Addition/Elimination of Enol Silyl Ethers

以二叔丁基过氧化物(DTBP)作氧化剂,氯仿或四氯化碳作三氯甲基自由基源及反应溶剂,由芳酮衍生的烯醇硅醚经自由基加成串联消除反应合成了β,β-二氯-α,β-不饱和酮,反应无需金属催化剂,条件温和,烯醇硅醚底物具有良好的普适性.

Using di-tert-butyl peroxide(DTBP)as oxidant,chloroform or carbon tetrachloride as trichloromethyl radical source and reaction solvent,enol silyl ethers derived from aryl ketone was transferred toβ,β-dichloro-α,β-unsaturated ketone by trichloromethyl radical addition/elimination.The conditions are mild with avoiding the use of metal catalysts,and the enol silyl ethers substrate has good universality.