p53在细胞增殖和迁移中对骨架重建的作用

Role of p53 in Cytoskeletal Reconstruction during Cell Proliferating and Migrating

p53作为最重要的抑癌因子之一,通常作为转录因子发挥肿瘤抑制作用。除转录活性外,p53及其突变型可能通过调节整合素、钙黏蛋白、Rho/ROCK信号通路等对肌动蛋白细胞骨架重建产生作用,从而影响细胞增殖和迁移。p53的这些功能在调节肌动蛋白细胞骨架重建以响应细胞外微环境和癌基因激活中起着至关重要的作用。

p53 is the most important tumor suppressor,and usually exerts tumor-suppressing effect as a transcription factor.Except for its transcriptional activity,p53 and its mutants may also have effects on cell proliferation and migration though other pathways,including integrin signaling,cadherin,and Rho/ROCK signaling.These multiple functions of p53 play crucial roles in regulating actin cytoskeletal reconstruction to respond to extracellular microenvironment and oncogene activation.