Nrf2在心血管疾病中的作用及机制

The Role of Nrf2 in Cardiovascular Diseases and Its Mechanism

作为一种重要的转录调节因子,自1994年被发现以来,Nrf2因其抗氧化和解毒作用引起了研究者的广泛兴趣。Nrf2主要通过结合靶基因启动子上的抗氧化应答元件(anti-oxidant response element,ARE),来转录激活下游靶基因的表达。心血管疾病致死者占全球死亡人数的31%,严重威胁人类健康。由于在抗氧化应激中的重要作用,Nrf2与心血管疾病发生发展关系密切,具有潜在治疗价值。该综述主要介绍了Nrf2作为转录因子的结构特点、上游调节机制和下游功能,并重点对近年来Nrf2在心血管疾病发生发展中的作用研究进展作一介绍。

As an important transcriptional factor,Nrf2(nuclear factor-erythroid 2-related factor 2)has attracted a lot of interest since its discovery in 1994,owing to its anti-oxidation and detoxification functions.Nrf2 transcriptionally activates the downstream target gene expression primarily by binding to ARE(antioxidant response element)in the promoter region of its target genes.The mortality of cardiovascular diseases accounts for 31%of global deaths,seriously threatening human health.Due to the significant role in anti-oxidative stress,Nrf2 is related to the occurrence and development of cardiovascular disease,with great therapeutic potential.This review mainly introduces the structure characteristics,upstream regulatory signals and downstream functions of Nrf2,also states the research progress of its pathological roles in cardiovascular diseases in recent years.