小鼠毛囊发育分子遗传学机制研究进展

Advances on Molecular Genetic Mechanisms of Mice Hair Follicle Development

毛囊作为皮肤的附属器官,具有不断进行组织再生的特点,是研究干细胞的一种理想模型。毛囊发育机制十分复杂,其形态发生与持续终生的再生循环过程涉及表皮(上皮)和真皮(间充质)之间的相互作用。现已有相关的小鼠遗传模型被用于研究毛囊发育及再生的分子机制。该综述介绍最新的小鼠遗传学研究,主要涉及在毛囊发育过程中分别来自表皮和真皮中关键信号分子的敲除或过表达,以描绘一个控制毛囊发育和周期性循环的信号网络,为深入立体地理解毛囊发育机制和临床毛发疾病发病机制提供理论依据。

HF(hair follicle)is an appendage of the skin.The HF is regarded as an excellent model for studying stem cell activity because it continuously proceeds through rounds of tissue regeneration.The mechanism of HF development is very complex.HF morphogenesis involves a temporal series of reciprocal interactions between the epithelium(epidermis)and its underlying mesenchyme(dermis).Transgenic mice have been used for studying the molecular mechanism of HF development and regeneration.This paper summarizes the over-expression or knock-out of key signal molecules from the epidermis and dermis during HF development in mice and prints the latest signal network that regulated HF development and cycling.It may provide a theoretical basis for an indepth understanding of HF development mechanism and hair diseases.