孕期胎盘生长因子动态检测联合高危因素对子痫前期的预测价值

Predictive value of dynamic detection of placental growth factor during pregnancy and high risk factors for pre-eclampsia

探讨胎盘生长因子(PLGF)在不同孕周单次检测与动态检测结合高危因素对子痫前期(PE)的预测价值,选取2019年1月至12月期间在本院行产检并分娩的PE孕妇52例为研究对象(研究组),同期抽取在本院行产前检查并分娩的非PE孕妇113例进行对照(对照组),根据建卡的孕周不同,分别于孕12~15周、16~20周、>20周后进行了PLGF单次检测或动态检测,并进行了高危因素筛查。结果显示,妊娠期糖尿病、孕前体重指数≥24、年龄≥35岁、辅助生殖技术妊娠、高血压病史等高危因素研究组明显高于对照组(P<0.05);研究组PLGF检测异常率明显高于对照组(P<0.05),动态检测异常率高于孕12~15周及孕16~20周单次检测异常率(P<0.05)。表明不同孕周PLGF的动态检测联合高危因素筛查对PE有一定预测价值。

To investigate the predictive value of placental growth factor(PLGF)during pregnancy with single test and dynamic test combined with high-risk factors for pre-eclampsia.A total of 52 pre-eclampsia patients who underwent prenatal examination and delivered in our hospital from January 1,2019 to December 31,2019 were selected as the research subjects(study group).113 non-preeclampsia pregnant women who were examined and delivered in our hospital were compared(control group).The gestational weeks were different according to the card.They were pregnant for 12-15 weeks,16-20 weeks,and>20 weeks.Later,a single or dynamic detection of PLGF was performed,and a screening of high-risk factors for pre-eclampsia was performed.The results showed that gestational diabetes high-risk factors such as BMI≥24,age≥35 years,pregnancy assisted reproductive technology,and history of hypertension were significantly higher in the study group than in the control group(P<0.05).The abnormal rate of PLGF detection in the research group was significantly higher than that in the control group(P<0.05),and the abnormal detection rate in the dynamic group was higher than the single detection abnormal rate in 12-15 weeks of pregnancy and 16-20 weeks of pregnancy(P<0.05).It shows that the dynamic detection of PLGF at different gestational weeks combined with screening for high risk factors has certain predictive value for PE.