慢性阻塞性肺疾病急性加重期老年病人血清白蛋白、前白蛋白、体质量指数与肺通气功能的相关性

Correlation study of serum albumin,prealbumin,BMI and pulmonary ventilation function in elderly patients with AECOPD

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)老年病人营养指标血清白蛋白、前白蛋白、体质量指数(BMI)与肺通气功能的相关性。方法选取安徽医科大学附属安庆医院2017年10月至2018年10月收治的AECOPD老年病人70例作为观察组,选取同时间段老年健康体检者70例作为健康组,比较两组血清白蛋白、前白蛋白、BMI和肺功能指标,分析血清白蛋白、前白蛋白、BMI水平与病人肺通气功能的关系。结果观察组血清白蛋白[35.80(34.10,37.20)g/L比43.10(40.90,45.50)g/L]、前白蛋白[(14.35±5.35)mg/L比(26.14±5.90)mg/L]、BMI水平[(19.96±2.75)kg/m^2比(22.74±2.16)kg/m^2]均低于健康组,差异有统计学意义(P<0.01);观察组FEVl/FVC[55.86(44.32,60.78)比90.32(85.91,94.20)]和FEV1%pred[43.90(27.90,64.60)比89.50(86.30,93.70)]均低于健康组,差异有统计学意义(P<0.01);不同肺功能级别病人间的血清白蛋白、前白蛋白、BMI水平比较,差异有统计学意义(P<0.01),血清白蛋白、前白蛋白、BMI水平随肺功能分级的升高而逐渐降低;AECOPD老年病人血清白蛋白、前白蛋白、BMI水平与FEVl/FVC和FEV1%pred均呈正相关,差异有统计学意义(P<0.01)。结论 AECOPD老年病人的营养指标血清白蛋白、前白蛋白、BMI水平均会出现降低,且与病人的肺通气功能密切相关,可以作为AECOPD病人病情监测的重要指标。

Objective To investigate the correlation between nutrition index,serum albumin,prealbumin,body mass index(BMI)and pulmonary ventilation function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Seventy elderly patients with AECOPD in Anqing Hospital Affiliated to Anhui Medical University from October 2017 to October 2018 were selected as the observation group,and 70 healthy persons in the same period were selected as the control group.The nutrition index,serum albumin,prealbumin,BMI and lung function index were compared between the two groups,the relationship between the level of serum albumin,prealbumin,BMI and pulmonary ventilation function was analyzed.Results Serum albumin[35.80(34.10,37.20)g/L vs.43.10(40.90,45.50)g/L],pre-albumin[(14.35±5.35)mg/L vs.(26.14±5.90)mg/L]and BMI[(19.96±2.75)kg/m^2 vs.(22.74±2.16)kg/m^2]of the observation group were lower than those of the control group,with statistically significant differences(P<0.01).FEV1/FVC[55.86(44.32,60.78)vs.90.32(85.91,94.20)]and FEV1%pred[43.90(27.90,64.60)vs.89.50(86.30,93.70)]in the observation group were lower than those in the control group(P<0.01).There were statistically significant differences in serum albumin,prealbumin and BMI between patients with different pulmonary function levels(P<0.01).The level of serum albumin,pre-albumin and BMI of nutritional indicators gradually decreased with the increase of pulmonary function grade.Serum albumin,prealbumin and BMI levels of elderly patients with AECOPD were positively correlated with FEV1/FVC and FEV1%pred,and the differences were statistically significant(P<0.01).Conclusion The nutritional indexes of elderly patients with AECOPD,such as serum albumin,pre-albumin and BMI,are abnormally reduced,and are closely related to the pulmonary ventilation function of patients,which can be used as an important indicator for monitoring the condition of patients with AECOPD.