线粒体解偶联蛋白2在肝癌组织中的表达及其与紫杉醇化疗耐药的关系

The clinical significance of UCP2 expression in hepatocellular carcinoma and its relationship with resistance to paclitaxel chemotherapy

目的研究线粒体解偶联蛋白2(uncoupling protein2,UCP2)在肝癌组织中表达的临床意义及其与紫杉醇化疗耐药的关系。方法选取2012年2月至2013年2月在仪陇县人民医院住院的肝癌病人120例,比较不同病理资料的UCP2水平,通过对病人展开为期5年的随访,比较不同预后及紫杉醇的耐药情况。结果肝癌组织UCP2阳性表达72例,表达率60.00%,高于癌旁组织的12例,表达率10.00%,不同组织分化、淋巴结转移、TNM分期、生存情况的UCP2水平及紫杉醇耐药情况比较,均差异有统计学意义(P<0.05);不同组织分化、淋巴结转移、TNM分期、生存情况及UCP2水平均为紫杉醇耐药的独立危险因素,UCP2水平与紫杉醇耐药情况呈正相关(P<0.05)。结论 UCP2阳性肝癌病人紫杉醇耐药性较高,生存情况较差,可作为病人预后评估的依据。

Objective To explore the clinical significance of uncoupling protein 2(UCP2)expression in hepatocellular carcinoma and its relationship with resistance to paclitaxel chemotherapy.Methods A hundred and twenty patients with hepatocellular carcinoma hospitalized in People’s Hospital of Yilong County from February 2012 to February 2013 were selected as the research subjects.UCP2 levels of patients with different pathological data were compared after admission.And the patients were followed up for five years to compare prognoses and paclitaxel resistance.Results The positive expression of UCP2 in hepatocellular carcinoma tissues was significantly higher than that in normal liver tissues[72 cases(60.00%)vs.12 cases(10.00%)].There were significant differences in UCP2 levels and paclitaxel resistance in different tissue differentiation,lymph node metastasis,TNM staging,and survival(P<0.05).Different tissue differentiation,lymph node metastasis,TNM staging,survival and UCP2 level were independent risk factors for paclitaxel resistance,and UCP2 level was positively correlated with paclitaxel resistance(P<0.05).Conclusion The patients with UCP2 positive hepatocellular carcinoma have high resistance to paclitaxel and poor survival,which can be used as a basis for prognosis evaluation.