血清CYFRA21-1、CEA、CA125联合检测在非小细胞肺癌中的诊断价值

Value of combined detection of serum CYFRA21-1,CEA and CA125 in diagnosis of non-small cell lung cancer

目的探讨血清癌胚抗原(CEA)、细胞角蛋白19可溶性片段(CYFRA21-1)及糖类抗原125(CA125)联合检测诊断非小细胞肺癌(NSCLC)的价值。方法选择45例NSCLC患者纳入观察组,并选择同期40例肺部良性病变患者纳入对照组,2组患者均检测CEA、CYFRA21-1及CA125水平,分析单项及联合检测的特异度、灵敏度、准确度。结果观察组CEA、CYFRA21-1及CA125水平均高于对照组,差异有统计学意义(P<0.05);相较于CEA、CYFRA21-1及CA125单项检测,联合检测的阳性检出率更高,差异具有统计学意义(P<0.05);相较于单项检测,联合检测的特异度、灵敏度、准确度均较高。结论应用血清CEA、CYFRA21-1及CA125联合检测对NSCLC具有较高的诊断价值,可为临床诊断、预后判断提供可靠依据。

Objective To investigate the value of combined detection of serum carcino-embryonic antigen(CEA),cytokeratin 19 fragment antigen 21-1(CYFRA21-1)and carbohydrate antigen 125(CA125)in non-small cell lung cancer(NSCLC).Methods A total of 45 patients with NSCLC were selected as observation group,and 40 patients with benign pulmonary lesions during the same period were selected as control group.The levels of CEA,CYFRA21-1 and CA125 of all patients were detected.The specificity,sensitivity,accuracy of single and combined detection were analyzed.Results The levels of CEA,CYFRA21-1 and CA125 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Compared with single detection of CEA,CYFRA21-1 or CA125,the positive detection rate of combined detection was higher,and the difference was statistically significant(P<0.05).The specificity,sensitivity and accuracy of combined detection were higher than those of single detection.Conclusion Combined detection of serum CEA,CYFRA21-1 and CA125 in NSCLC has higher diagnostic value,which can provide a reliable basis for the clinical diagnosis and prognostic judgement.