长链非编码RNA与胰腺相关疾病的研究进展

Progress of the research on long-chain non-coding RNA and pancreas related diseases

长链非编码RNA是一种长度大于200个核苷酸的非编码RNA,可在表观遗传、转录以及转录后三个水平调控基因的表达,具有多种生物学功能。胰腺作为人体中最主要、最复杂的器官之一,其生理作用和病理变化均与机体健康息息相关。本文通过搜集大量国内外相关文献,描述并归纳了长链非编码RNA在胰腺疾病,如胰腺炎、胰腺癌、糖尿病中所发挥的作用。本综述旨在提高临床医生对胰腺相关疾病的认知及为其提供新的诊疗方向,并为以后LncRNAs在胰腺疾病中的功能研究奠定基础。

Long-chain non-coding RNA is a non-coding RNA with a length of more than 200 nucleotides.It can regulate gene expression at epigenetic,transcriptional and post-transcriptional levels,and it has a variety of biological functions.Pancreas is one of the most important and complicated organs in human body.Its physiological function and pathological changes are closely related to body health.This paper described and summarized the role of long-chain non-coding RNA in pancreatic diseases such as pancreatitis,pancreatic cancer and diabetes by collecting a large number of relevant domestic and foreign literatures.The purpose of this review is to improve clinicians'understanding of pancreas related diseases and provide a new diagnosis and treatment direction for them,and lay a foundation for future research on the function of LncRNAs in pancreatic diseases.