PCT、CRP在肺炎支原体肺炎患儿中的表达及与MP-IgM抗体的关系

Expression of procalcitonin and C-reactive protein in children with Mycoplasma pneumoniae pneumonia and its relationship with MP-IgM antibody

目的探究降钙素原(PCT)、C反应蛋白(CRP)在肺炎支原体肺炎(MPP)患儿中的表达及与MP-IgM抗体的关系.方法选取本院2016年5月至2019年5月肺炎患儿116例作为研究对象,其中MPP患儿82例作为观察组,病毒感染性肺炎34例作为对照组.检测对比两组血清PCT、CRP水平,采用受试者工作特征曲线(ROC曲线)及ROC下面积(AUC)血清PCT、CRP及联合检测对MPP与病毒感染性肺炎的鉴别诊断价值.对比不同MP-IgM抗体滴度患儿血清PCT、CRP水平,Spearman分析血清PCT、CRP与MP-IgM抗体滴度相关性.比较不同疗效患儿治疗前后血清PCT、CRP水平变化趋势.结果观察组血清PCT、CRP、MP-IgM抗体水平高于对照组(P<0.05);PCT诊断MPP的AUC为0.744,CRP诊断MPP的AUC为0.787,PCT+CRP诊断MPP的AUC为0.840(P<0.05);血清PCT、CRP水平随MP-IgM抗体滴度增加呈不断升高趋势(P<0.05);血清PCT、CRP与MP-IgM抗体呈正相关(P<0.05);好转患儿治疗3、5、7 d后血清PCT、CRP水平低于未好转患儿(P<0.05).结论PCT、CRP在MPP患儿中表达明显升高,可作为诊断MPP与疗效评估的指标,且PCT、CRP表达与MP-IgM抗体有关.

Objective To investigate the expression of procalcitonin(PCT)and C-reactive protein(CRP)in children with Mycoplasma pneumoniae pneumonia(MPP)and the relationship with MPIgM antibody.Methods 116 patients with pneumonia in our hospital from May 2016 to May 2019 were selected as the research object,of which 82 cases of MPP children served as the observation group,and 34 cases of viral infectious pneumonia served as the control group.Serum PCT and CRP levels were compared between the 2 groups,the value of the receiver operating characteristic curve(ROC)curve and the area under the ROC(AUC)of serum PCT,CRP and combined detection was used for the differential diagnosis of MMP and viral infectious pneumonia.Comparing serum PCT and CRP levels in children with different MP-IgM antibody titers,Spearman was used to analyze the correlation between serum PCT,CRP and MP-IgM antibody titers.The changes of serum PCT and CRP levels before and after treatment in children with different therapeutic effects were compared.Results Serum PCT,CRP and MP-IgM antibody levels in the observation group were higher than those in the control group(P<0.05);the AUC for MPT diagnosis by PCT was 0.744,the AUC for MPP diagnosis by CRP was 0.787,and the AUC for MPP diagnosis by PCT+CRP was 0.840(P<0.05).Serum PCT and CRP levels showed an increasing trend with increasing MP-IgM antibody titers(P<0.05);serum PCT,CRP and MP-IgM antibody were positively correlated(P<0.05);the levels of serum PCT and CRP in children who improved after treatment for 3,5,and 7 days after treatment were lower than those who did not improve(P<0.05).Conclusion The expression of PCT,CRP and MP-IgM antibodies is significantly increased in children with MPP,which can be used as an indicator for the diagnosis of MPP and the evaluation of therapeutic effects.The expression of PCT and CRP is related to MP-IgM antibodies.