美沙拉嗪肠溶片联合还原型谷胱甘肽片治疗慢性结肠炎的疗效及免疫功能分析

Analysis of the Efficacy and Immune Function of Mesalazine Enteric-coated Tablets Combined with Reduced Glutathione Tablets in the Treatment of Chronic Colitis

目的探究美沙拉嗪与还原性谷胱甘肽对慢性结肠炎患者临床疗效和免疫功能的影响。方法从2018年1—12月期间在该院进行治疗的慢性结肠炎患者中随机抽取70例参与研究,根据数字表法进行随机分组,包括对照组(n=35)和观察组(n=35),两组患者均开展常规疗法,对照组患者在常规疗法基础上给药美沙拉嗪肠溶片治疗,观察组患者在常规治疗和美沙拉嗪肠溶片基础上给药还原型谷胱甘肽片治疗,对两组患者的临床治疗总有效、治疗后免疫功能指标以及不良反应发生率等进行比较分析。结果观察组患者临床治疗总有效率97.14%高于对照组80.00%,差异有统计学意义(χ2=5.081,P<0.05);观察组患者治疗后免疫功能指标中CD3+、CD4+和CD4+/CD8+均高于对照组,而CD8+显著低于对照组,数据差异有统计学意义(P<0.05);观察组患者不良反应发生率5.71%显著低于对照组22.86%,差异有统计学意义(χ2=4.200,P<0.05)。结论针对慢性结肠炎患者的治疗采用美沙拉嗪肠溶片与还原型谷胱甘肽片联合疗法能够有效提升患者临床疗效,增强其免疫功能,并降低不良反应风险,对患者的病情控制和康复具有积极影响。

Objective To investigate the effects of mesalazine and reduced glutathione on clinical efficacy and immune function in patients with chronic colitis.Methods From January to December 2018,70 patients with chronic colitis treated in the hospital were randomly selected to participate in the study and randomly divided according to the numerical table method,including the control group(n=35) and the observation group(n=35),patients in both groups were treated with conventional therapy,patients in the control group were given mesalazine enteric-coated tablets on the basis of conventional therapy,and patients in the observation group were given reduced form on the basis of conventional therapies and the treatment of glutathione tablets was used to compare and analyze the clinical efficacy,immune function indexes and incidence of adverse reactions of the two groups.Results The total effective rate of clinical treatment in the observation group was 97.14% higher than that in the control group,80.00%.The significantly different statistically significant(χ2=5.081,P<0.05).The CD3+ in the immune function index of the observation group after treatment CD4+,CD4+ and CD4+/CD8+ are all higher than the control group,while CD8+was significantly lower than the control group.The difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 5.11% significantly lower than the control group 22.86%,the difference was statistically significant(χ2=4.200,P<0.05).Conclusion The treatment of patients with chronic colitis with mesalazine enteric-coated tablets and reduced glutathione tablets can effectively improve the clinical efficacy of patients,enhance their immune function,and reduce the risk of adverse reactions.Rehabilitation has a positive impact.