巴曲酶注射液联合丁苯酞软胶囊治疗突发性聋患者的临床疗效

Clinical effect of Basozyme Injection combined with Butylphthalide Soft Capsules in the treatment of sudden deafness

目的观察巴曲酶注射液联合丁苯酞软胶囊治疗突发性聋患者的临床疗效。方法将确诊为突发性聋的患者108例随机分为对照组和联合丁苯酞干预组,每组54例。比较治疗前和治疗14 d后血液学指标(纤维蛋白原含量、血浆比黏度、全血黏度)、纯音听阈、眩晕及耳鸣伴随症状消失时间、临床疗效。结果治疗后2组患者血液学指标均显著优于治疗前,且联合丁苯酞干预组显著优于对照组(P<0.05);2组患者纯音听阈值较治疗前均显著下降,且联合丁苯酞干预组较对照组下降更显著(P<0.05);联合丁苯酞干预组患者眩晕及耳鸣消失时间较对照组显著缩短(P<0.05);联合丁苯酞干预组治疗总有效率显著高于对照组(P<0.05)。结论巴曲酶注射液联合丁苯酞软胶囊治疗对突发性聋患者有显著疗效。

Objective To observe the clinical effect of Basozyme Injection combined with Butylphthalide Soft Capsules in the treatment of sudden deafness.Methods A total of 108 patients confirmed as sudden deafness were randomly divided into control group(n=54)and combined butylphthalide intervention group(n=54).The hematological indexes(fibrin content,ratio of viscosity,whole blood viscosity),pure tone hearing threshold,disappeared time of accompanied symptoms such as vertigo and tinnitus and clinical efficacy before and afteR14 days of treatment in two groups were compared.Results AfteRtreatment,the hematological indexes of the two groups were betteRthan those before treatment,and the hematological indexes of combined butylphthalide intervention group were significantly betteRthan those of control group(P<0.05).The pure tone hearing thresholds of the two groups were loweRthan that before treatment,and the decrease degree of combined butylphthalide intervention group was significantly loweRthan that of control group(P<0.05).The disappearance time of vertigo and tinnitus in combined butylphthalide intervention group was significantly shorteRthan that in control group(P<0.05).The total effective rate of combined butylphthalide intervention group was significantly higheRthan that of control group(P<0.05).Conclusion The combined treatment of Basozyme Injection and Butylphthalide Soft Capsules has a remarkable effect on sudden deafness.