艾司西酞普兰联合氨磺必利治疗老年抑郁症患者的效果

Effect of escitalopram combined with amisulpride in the treatment of elderly patients with depression

目的探讨艾司西酞普兰联合氨磺必利治疗65岁以上抑郁症患者的效果及对负性情绪的影响。方法回顾性分析190例65岁以上抑郁症患者的临床资料,并按治疗方案不同分为2组。将单纯应用艾司西酞普兰治疗的患者设为对照组(n=95),将采取艾司西酞普兰联合氨磺必利治疗的患者设为研究组(n=95)。比较2组治疗效果、治疗前后负性情绪变化以及副反应发生率。结果研究组患者的抑郁症总体治疗有效率为97.89%,显著高于对照组的90.53%(P<0.05);治疗后,研究组和对照组的症状自评量表(SCL-90)评分均显著低于治疗前,且研究组SCL-90评分显著低于对照组(P<0.05);研究组患者的副反应发生率为4.21%,显著低于对照组的13.68%(P<0.05)。结论艾司西酞普兰联合氨磺必利治疗65岁以上抑郁症患者的临床效果显著,可有效消除患者负性情绪,且安全性较高。

Objective To explore the effect of escitalopram combined with amisulpride in the treatment of depression patients aged over 65 years and its impact on negative emotions. Methods The clinical data of 190 patients with depression aged over 65 years who were diagnosed and treated in our hospital was analyzed retrospectively,and they were divided into two groups according to different treatment plans: the patients treated with escitalopram alone were selected as control group (n = 95),and those treated with escitalopram combined with amisulpride were selected as study group (n =95). The therapeutic efficacy,changes of negative emotions before and after treatment and the incidence of adverse reactions were statistically analyzed. Results The total effective rate of depression in the study group was higher than that in the control group (97. 89% vs. 90. 53%,P < 0. 05);after treatment,the Symptom Checklist 90 (SCL-90) scores in the study group and the control group were lower than that before treatment,and was lower in the study group than that of the control group (P <0. 05);the incidence of side effects in the study group was lower than that in the control group (4. 21% vs. 13. 68%,P < 0. 05). Conclusion Escitalopram combined with amisulpride in the treatment of depression patients aged over 65 years has significant efficacy,which can effectively eliminate the negative emotions of patients,and has higher safety.