冷冻胚胎移植周期妊娠结局的影响因素分析

Influencing factors of pregnancy outcome of frozen embryo transfeRcycle

目的探讨影响冷冻胚胎移植周期妊娠的危险因素。方法回顾性分析15848个冷冻胚胎移植周期(15848例冷冻胚胎移植患者)的资料,追踪妊娠结局,根据妊娠结局的不同分为妊娠组9459例和未妊娠组6389例,收集患者年龄、不孕年限、不孕类型、雌激素水平、内膜准备方式、移植日内膜厚度等临床资料。采用多因素Logistic回归分析影响冷冻胚胎移植周期妊娠的因素。结果本组最终完成胚胎/囊胚移植27104个,临床妊娠率59.69%(9459/15848)。单因素分析显示年龄、胚龄、移植胚胎/囊胚数、移植日内膜厚度与临床妊娠率有关(P<0.01)。Logistic回归分析显示年龄、移植日内膜厚度、移植胚胎/囊胚数、胚龄是临床妊娠结局的影响因素(P<0.05或P<0.01)。结论患者年龄、移植日内膜厚度、移植胚胎/囊胚数、胚龄是冷冻胚胎移植临床结局的影响因素。

Objective To explore the risk factors of pregnancy of frozen embryo transfeRcycle.Methods Clinical data of 15848 frozen embryo transfeRcycles(15848 patients with frozen embryo transfer)was retrospectively analyzed and pregnancy outcomes were tracked.According to different pregnancy outcomes,the patients were divided into pregnancy group(9459 cases)and non-pregnancy group(6389 cases).Clinical data such as age,infertility duration,type of infertility,estrogen level,endometrial preparation method,endometrial thickness on transplantation day were collected.Multivariate Logistic regression analysis was used to analyze the factors affecting pregnancy in frozen embryo transfeRcycle.Results A total of 27104 embryos/blastula were transferred in this group,with clinical pregnancy rate of 59.69%(9459/15848).Univariate analysis showed that age,embryo age,numbeRof embryos/blastula transferred,and endometrium thickness on transplantation day were related to clinical pregnancy rate(P<0.01).Logistic regression analysis showed that age,endometrial thickness on transplantation day,numbeRof embryos/blastula transferred,embryo age were risk factors affecting clinical pregnancy outcomes(P<0.05 oRP<0.01).Conclusion Patients′age,endometrial thickness on transplantation day,numbeRof embryos/blastula transferred,embryo age are influencing factors of clinical outcomes of frozen embryo transfer.