左卡尼汀联合营养素治疗特发性弱畸精子症男性不育的疗效评价

Evaluation on efficacy of levocarnitine combined with nutrient therapy in the treatment of idiopathic asthenospermia in males with infertility

目的探讨左卡尼汀联合营养素治疗特发性弱畸精子症男性不育的疗效。方法选择72例特发性弱畸精子症男性不育患者作为研究对象,按照治疗方案的不同将患者分为观察组与对照组,各36例。对照组采用常规维生素E联合辅酶Q10治疗,观察组采用左卡尼汀联合营养素治疗。观察2组患者治疗3个月后的各项精液参数,对临床疗效进行综合评价。结果治疗后2组患者精液量、精子浓度、精子活力、精子DNA完整率以及正常形态精子率均优于治疗前,且观察组患者以上各指标优于对照组,差异均有统计学意义(P<0.05)。结论左卡尼汀联合营养素治疗特发性弱畸精子症男性不育疗效可靠,能显著改善患者精液质量。

Objective To investigate the efficacy of levocarnitine combined with nutrient therapy in the treatment of idiopathic asthenospermia in males with infertility.Methods A total of 72 infertility males with idiopathic asthenospermia were recruited as study objects,and were divided into observation group and control group according to different treatment plans,with 36 cases in each group.The control group was treated with routine vitamin E and coenzyme Q10,and the observation group was treated with levocarnitine combined with nutrient therapy.The semen parameters of two groups were observed afteR3 months of treatment,and the clinical efficacy was comprehensively evaluated.Results AfteRtreatment,semen volume,sperm concentration,sperm motility,sperm DNA integrity rate and normal morphology sperm rate in the two groups were betteRthan pre-treatment,and the above indicators in the observation group were significantly betteRthan those in the control group(P<0.05).Conclusion Combination of levocarnitine and nutrient therapy in the treatment of infertility men with idiopathic asthenozoospermia has reliable efficacy and can significantly improve the quality of semen.