果蝇Catsup基因在卵巢中表达降低对生殖的影响

Effects of reduced expression of Catsup gene in the ovary of Drosophila melanogaster on reproduction

人类生殖健康是种族繁衍的重要基石,任一环节发生问题都可导致生殖障碍。当今社会,生殖障碍非常普遍,但是原因不明,也缺乏有效的调控手段。微量金属元素作为人体必需的营养元素,在多种生理过程中发挥着至关重要的作用。文章发现果蝇基因Catsup在卵巢中突变后会显著降低雌性果蝇的生殖能力,这些果蝇极有可能是由于卵巢发育障碍导致生殖能力的降低。生物信息学分析显示,Catsup编码的蛋白极可能是一个定位在高尔基体上的转锌蛋白,因此可能Catsup通过调控卵巢内锌离子稳态影响了雌性生殖能力。该研究为后续探究锌离子对雌性生殖的影响提供了有利模型,将为探究雌性生殖障碍提供新的线索。

Human reproductive health is an important cornerstone of racial reproduction,any linkage problems can lead to reproductive disorders.In today’s society,reproductive disorders are very common,but the reasons are not clear,and there is no effective means of regulation and control.As a necessary nutrient element for human body,trace metal elements play a vital role in many physiological processes.In this study,we found that the mutation of the Drosophila gene Catsup in the ovary significantly reduced the reproductive capacity of female Drosophila melanogaster,and these Drosophila melanogaster were most likely to have a reduction in reproductive capacity due to ovarian dysplasia.Bioinformatics analysis showed that the protein encoded by Catsup was probably a zinc-transferring protein located in Golgi apparatus,so Catsup may affect female reproductive ability by regulating zinc homeostasis in ovaries.This will provide a favorable model for the follow-up study of the effect of zinc ions on female reproduction,and provide a new clue for the study of female reproductive disorders.