抗菌肽共轭修饰的研究进展

Progress on Conjugated Modification of Antimicrobial Peptides

抗生素的广泛应用造成了抗生素残留和细菌耐药性等问题,亟待开发高效、安全的抗生素替代产品。抗菌肽是一类具有广谱抗菌活性的阳离子多肽,是抗生素的理想替代药物。但是天然抗菌肽的活性和稳定性较差,目前抗菌肽的共轭修饰对解决上述问题有重要作用。论文全面概述了抗菌肽的分类、作用机制和共轭修饰方面的研究进展,着重讨论了抗菌肽与抗生素修饰、脂化修饰、光敏剂修饰、微粒化和聚合化、金属有机化合物修饰和靶向修饰方面的研究进展,以期为新型抗菌肽药物的研究和应用提供参考。

The widespread use of antibiotics has caused the problems of antibiotic residues and bacterial resistance.It is urgent to develop efficient and safe antibiotic substitutes.Antimicrobial peptides are a kind of cationic peptides with broad-spectrum antibacterial activity,which are ideal substitutes for antibiotics.However,the activity and stability of natural antimicrobial peptides are not enough.At present,the conjugated modification of antimicrobial peptides has great potential in improving the activity and safety of antimicrobial peptides.In this paper,we summarized the classification,mechanism of action and conjugated modification of antimicrobial peptides,and mainly discussed the conjugated modification and application in order to provide new ideas for the research and development of antimicrobial peptides.