葛根素制剂的研究进展

Research Progress of Puerarin Preparation

葛根素是中药葛根的活性成分之一,具有舒张血管、抗氧化、保护神经细胞及免疫调节等药理作用。但是葛根素的溶解度和生物利用度低、半衰期短。目前在临床使用的葛根素注射液、葛根素滴眼液、葛根素片等普通制剂存在需要多次、大剂量给药,此外葛根素注射液还有溶血、致敏等风险,限制了葛根素的临床应用。针对这些问题,现已开发出多种葛根素的新剂型,可提高葛根素的溶解度、生物利用度。

Puerarin is one of the active components of Radix Pueraria with many pharmacological effects such as vasodilation,antioxidation,nerve cell protection and immune regulation etc.However,the solubility and bioavailability of puerarin are low and its half-life is short.Puerarin injection,puerarin eye drops,puerarin tablets and other common preparations in clinics need multiple and large doses.In addition,puerarin injection has the risks of hemolysis and allergic reactions,which limits the clinical application of puerarin.To solve these problems,varieties of puerarin preparations have been developed,which can improve the solubility and bioavailability of puerarin.In this paper,the preparation methods,physicochemical properties and evaluation results both in vitro and in vivo of these new preparations are introduced to provide reference for the development of new puerarin preparations.