肠道菌群与脊髓损伤并发症

Gut microbiota and complications of spinal cord injury

脊髓损伤是严重的致残性神经系统疾病,脊髓损伤后产生的水肿、炎症反应和代谢紊乱等并发症是致使脊髓损伤继发性加重的主要原因。近年来,随着对肠道微生物的研究越来越深入,肠道菌群对神经系统疾病的影响得到广泛关注。肠道菌群可以通过调节机体能量代谢、炎症反应及作用于神经内分泌和脑-肠轴的途径影响中枢神经系统疾病。最近研究发现,肠道菌群与脊髓损伤并发症的关系非常紧密。脊髓损伤后肠道菌群的变化可能影响脊髓损伤后并发症发生以及加重。本文主要就肠道菌群对脊髓损伤后并发症的影响和可能的作用机制进行综述,为临床研究和治疗脊髓损伤提供新思路。

Spinal cord injury(SCI) is a serious neurological disease causing disability. Complications such as edema, inflammatory reaction and metabolic disorder after SCI can aggravate the injury of spinal cord tissue. In recent years, with more and more studies on gut microbiota, the effect of gut microbiota on nervous system diseases has been widely concerned. Gut microbiota affect central nervous system diseases by regulating body′s metabolisms, inflammatory reactions, neuroendocrinology and brain-gut axis. Recent studies indicated that gut microbiota is closely related to the complications of spinal cord injury. The changes of gut microbiota after SCI may affect the occurrence and aggravation of complications after SCI. This article reviews the effect of gut microbiota on complications of SCI and its possible mechanism, suggesting novel therapeutic targets for SCI.