IL-10基因-1082A/G多态性与糖尿病肾病易感性的Meta分析

Association Between IL-10 Fene-1082A/G Polymorphism and the Risk of Diabetic Nephropathy:a Meta-analysis

目的系统评价白细胞介素-10(interleukin-10,IL-10)基因-1082A/G多态性与糖尿病肾病(diabetic nephropathy,DN)易感性之间的关系。方法检索建库以来至2019年6月间与IL-10基因1082A/G及DN发病风险相关的病例对照研究,使用纽卡斯尔渥太华(Newcastle-Ottawa Scale,NOS)标准对纳入文献进行质量评价。采用STATA12.0软件进行统计分析,选择发病风险比值比(odds ratio,OR)及95%置信区间(confidence interval,CI)为效应指标。结果本研究共纳入10项研究,包含DN患者1759例,单纯糖尿病(diabetes mellitus,DM)患者1525例,健康对照(healty control,HC)者2209例。DN组与单纯DM组比较,IL-10基因-1082A/G多态性在各遗传模型上差异均无统计学意义(P>0.05)。DN组与健康人群比较,IL-10基因-1082A/G多态性在纯合子模型下与DN呈明显相关性(GG vs AA:OR=0.577,P<0.05)。将地区进行亚组分析发现,亚洲人群中IL-10基因-1082A/G多态性在除杂合子模型外的其他遗传模型中差异均有统计学意义(G vs A:OR=0.589,P=0.031;GG vs AA:OR=0.349,P=0.000;GG vs GA+AA:OR=0.588,P=0.015;GG+GA vs AA:OR=0.629,P=0.000)。结论IL-10基因-1082A/G多态性与DN发病相关,亚洲人群中G等位基因、GG基因型是DN发病的保护因素。

Objective To assess the relationship between Interleukin-10(IL-10)gene-1082A/G polymorphism and the risk of diabetic nephropathy(DN)via Meta-analysis.Methods The databases were searched for articles published since the establishment of the library to June 2019.We chosed the case-control studies which were associated with-1082A/G and DN,and the quality of articles were evaluated by Newcastle Ottawa scale(NOS)standard.We used incidence risk odds ratio(OR)and 95%confidence interval(CI)as the effect indicators by STATA12.0.Results Ten studies were eligible in this study,including 1759 diabetic nephropathy patients,1525 diabetic mellitus(DM)patients and 2209 healthy controls(HC).There was no significant difference in-1082A/G gene polymorphism between diabetic nephropathy group and diabetic mellitus group(P>0.05).There was a significant correlation between-1082A/G polymorphism and DN in the homozygous model(GG vs AA:OR=0.577,P<0.05).The subgroup analysis showed that,in addition to the heterozygous model,there was statistical difference in-1082A/G gene polymorphism in other genetic models(G vs A:OR=0.589,P=0.031;GG vs AA:OR=0.349,P=0.000;GG vs GA+AA:OR=0.588,P=0.015;GG+GA vs AA:OR=0.629,P=0.000).Conclusion The data suggested that the IL-10 gene-1082A/G polymorphism could play a significant role in the development of DN.G allele and GG genotype were the protective factors of DN in Asian population.