摘要
目的:探讨双歧杆菌乳杆菌三联活菌片(金双歧片)对诺如病毒性肠炎的疗效、炎性因子及肠道菌群的影响。方法:选取2018年6月~2018年12月于某院消化内科诊治的诺如病毒性肠炎患者共49例,随机数表法分为对照组(24例)和观察组(25例),对照组温水冲服蒙脱石散,观察组在对照组基础上加用金双歧片,观察治疗前后临床症状消失时间、炎性因子(IL-6、TNF-α)及肠道菌群情况,分析临床总有效率。结果:观察组与对照组相比,临床症状减退时间缩短(P<0.05),临床总有效率提高(P<0.05);治疗后两组IL-6、TNF-α与治疗前相比下降(P<0.05)且观察组下降明显(P<0.05);治疗后观察组肠道菌较治疗前增多(P<0.05),且观察组与照组相比也增多(P<0.05)。结论:双歧杆菌乳杆菌三联活菌片对诺如病毒性肠炎的临床症状、临床疗效、炎性因子及肠道菌群均有改善效果,建议在临床上推广应用。
Objective:To investigate the effect of bifidobacterium triple viable tablet(bifidobacterium aureus tablet)on norovirus enteritis,inflammatory factors and intestinal flora.Methods:a total of 49 norovirus enteritis patients who were diagnosed and treated in the digestive department of a hospital from June 2018 to December 2018 were selected and randomly divided into the control group(24 cases)and the observation group(25 cases).The control group was treated with montmorillonite powder with warm water,and the observation group was treated with bifidobacterium triple viable tablet on the basis of the control group.The time of clinical symptoms disappearance,inflammatory factors(IL-6,TNF-α)and intestinal flora were observed before and after treatment.Results:Compared with the control group,the time of clinical symptom reduction in the observation group was shortened(P<0.05),and the total effective rate was increased(P<0.05).After treatment,the IL-6 and TNF-αin the two groups was decreased(P<0.05),and the observation group was decreased significantly(P<0.05).After treatment,the intestinal flora in the observation group was increased(P<0.05),and that in the observation group was also increased compared with the control group(P<0.05).Conclusion:Bifidobacterium lactobacillus triple viable tablet can improve the clinical symptoms,clinical efficacy,inflammatory factors and intestinal flora for norovirus enteritis,which is worthy of clinical promotion and application.
作者
文海聆
姚业科
唐志林
Wen Hailing;Yao Yeke;Tang Zhilin(Tonghu Health Center,Zhongkai Hi-tech Industrial Development Zone,Huizhou 516039)
出处
《数理医药学杂志》
2020年第8期1167-1169,共3页
Journal of Mathematical Medicine
关键词
双歧杆菌乳杆菌三联活菌片
诺如病毒性肠炎
肠道菌群
bifidobacterium lactobacillus triple viable tablet
norovirus enteritis
intestinal flora