阿奇霉素治疗小儿支原体肺炎的效果评价

Evaluation of Azithromycin in Mycoplasma Pneumonia in Children

目的研究阿奇霉素对小儿支原体肺炎的治疗效果。方法方便选取该院于2017年3月—2018年1月期间收治的90例小儿支原体肺炎患者,通过区组随机化法将患者划分成对照组和研究组,各45例,分别使用红霉素和阿奇霉素进行治疗,对两组治疗效果进行研究分析。结果研究组治疗有效率(95.55%)高于对照组(82.22%),差异有统计学意义(χ^2=4.050,P=0.044);不良反应发生率(8.89%)低于对照组(26.67%),差异有统计学意义(χ^2=4.865,P=0.027);研究组咳嗽消失时间、肺部啰音消失时间、肺部阴影消失时间、退热时间、喘息时间、住院时间分别为(9.62±0.98)、(9.26±2.22)、(12.26±2.22)、(8.50±1.35)、(2.22±1.01)、(13.34±2.01)d,对照组咳嗽消失时间、肺部啰音消失时间、肺部阴影消失时间、退热时间、喘息时间、住院时间分别为(15.38±1.94)、(13.89±2.55)、(16.25±2.44)、(13.45±1.86)、(5.13±2.04)、(17.64±2.16)d其数据与对照组相比较差异有统计学意义(t=17.778,P=0.000;t=9.186,P=0.000;t=8.114,P=0.000;t=14.448,P=0.000;t=8.670,P=0.000;t=9.776,P=0.000)。结论为小儿支原体肺炎患者使用阿奇霉素进行治疗,效果显著,生活质量评分得到提升,有利于病情恢复,值得大力推广。

Objective To study the effect of azithromycin on mycoplasma pneumonia in children.Methods Ninety patients with mycoplasma pneumonia in the hospital between March 2017 and January 2018 were conveniently selected,and the patients were divided into control group and study group by block randomization method.The number of cases in each group was 45.Erythromycin and azithromycin were used for treatment,and the treatment effects of the two groups were analyzed.Results The treatment group's effective rate(95.55%)was higher than that of the control group(82.22%),and the difference was significant(χ^2=4.050,P=0.044).The incidence of adverse reactions(8.89%)was lower than that of the control group(26.67%),and the difference was significant(χ^2=4.865,P=0.027);cough disappearance time,lung murmur disappearance time,lung shadow disappearance time,antipyretic time,wheezing time,and hospital stay were(9.62±0.98)d,(9.26±2.22)d,(12.26±2.22)d,(8.50±1.35)d,(2.22±1.01)d,(13.34±2.01)d,cough disappearance time,lung murmur disappearance time,lung shadow disappearance time in the control group,antipyretic time,wheezing time,and hospitalization time were(15.38±1.94)d,(13.89±2.55)d,(16.25±2.44)d,(13.45±1.86)d,(5.13±2.04)d,(17.64±2.16)d.There was a significant difference between the data and the control group(t=17.778,P=0.000;t=9.186,P=0.000;t=8.114,P=0.000;t=14.448,P=0.000;t=8.670,P=0.000;t=9.776,P=0.000).Conclusion The use of azithromycin in the treatment of children with mycoplasmal pneumonia has a significant effect,and the quality of life score is improved,which is conducive to the recovery of the disease and is worthy of vigorous promotion.