还原叶酸载体基因A80G多态性与神经管畸形易感性关系的Meta分析

Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects

目的系统评价母亲及子代还原叶酸载体(RFC1)基因A80G多态性与神经管畸形(NTDs)发病风险的相关性,为NTDs的预防提供依据。方法检索从建库到2019年5月在中国生物医学文献数据库、中国期刊全文数据库、万方数据库和PubMed、Embase、Cochrane Library数据库公开发表的有关母亲和/或子代RFC1 A80G多态性与NTDs易感性相关的病例对照研究,应用RevMan 5.3软件对各文献进行Meta分析。结果1)有关母亲RFC1 A80G多态性与NTDs易感性文献的Meta分析显示,亚洲人群中RFC1基因A80G位点GG vs AA、GA vs AA、GG+GA vs AA和G vs A各遗传模型与子代NTDs易感性之间有关联性,OR值(95%CI)分别为4.13(1.97~8.67)、3.03(1.72~5.32)、3.25(1.90~5.56)、1.94(1.15~3.28)。2)有关子代RFC1 A80G多态性与NTDs易感性文献的Meta分析显示,亚洲人群中子代RFC1 A80G位点GG vs AA、GG+GA vs AA、GG vs GA+AA和G vs A各遗传模型与NTDs易感性之间有关联性,OR值(95%CI)分别为2.20(1.34~3.63)、1.58(1.02~2.46)、1.89(1.31~2.72)、1.55(1.21~1.98)。结论在亚洲人群中母亲及子代RFC1基因A80G位点多态性是NTDs发病的遗传易感因素之一。

Objective To systematically evaluate associations between gene polymorphism of maternal and offsprings'reduced folate carrier(RFC1)A80G and the risk of neural tube defects(NTDs),so as to provide evidence for the prevention of NTDs.Methods Case-control study on the correlation between RFC1 A80G polymorphism of maternal and/or offspring'with NTDs were searched in CBM,CNKI,Wan-Fang Data,Pubmed,Embase and Cochrane Library from establishment of the database to May 2019.And RevMan 5.3 software was used to analyze data.Results 1)There was significant association between maternal RFC1 A80G polymorphism and increasing risk of NTDs in Asia(GG vs.AA:OR=4.13,95%CI:1.97―8.67;GA vs.AA:OR=3.03,95%CI:1.72―5.32;GG+GA vs.AA:OR=3.25,95%CI:1.90―5.56;G vs.A:OR=1.94,95%CI:1.15―3.28).2)There was significant association between offsprings'RFC1 A80G poly morphism and increasing risk of NTDs in Asia(GG vs.AA:OR=2.20,95%CI:1.34―3.63;GG+GA vs.AA:OR=1.58,95%CI:1.02―2.46;GG vs.GA+AA:OR=1.89,95%CI:1.31―2.72;G vs.A:OR=1.55,95%CI:1.21―1.98).Conclusion Both maternal and offsprings'RFC1 A80G polymorphism are risk factors of NTDs in Asian population.