Substantia nigra hyperechogenicity in Parkinson disease patients with leucine-rich repeat kinase 2 variants in the Chinese Han population

To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disease,and is characterized by both motor and non-motor symptoms.The leucine-rich repeat kinase 2(LRRK2)gene,characterized by different mutations among different populations,is well-known in both familial and sporadic PD.The frequency of theG2019S mutation is 20%to 40%in the Ashkenazi Jewish and North African Arab populations,while G2385R is a common risk factor associated with Asian populations.Research teams have found that G2385R is also associated with PD in the Chinese Han population,suggesting a clear contribution of this mutation to the Han population,but descriptions of clinical PD symptoms in the Chinese Han population are rare and warrant further G2385R genotype-phenotype analyses.