鼻部菌群在慢性鼻窦炎中的作用

Role of nasal microbiome in chronic sinusitis

慢性鼻窦炎(chronic sinusitis,CRS)是鼻窦及鼻腔的慢性炎性疾病,大约影响10.9%的欧洲成年人,造成了巨大的经济负担[1]。尽管CRS患病率很高,但对该病的病因尚未达成共识[2]。一直以来,我们把真菌、先天性免疫功能低下、细菌生物膜、金黄色葡萄球菌超抗原、慢性骨细胞炎和味觉受体的遗传改变当做CRS的潜在病因[3]。通过应用新一代测序技术,我们对人类体内的微生物群进行研究分析,发现几乎每个黏膜表面都存在多样的、特定于生态位的微生物群落,它包含环境中全部的遗传信息。

Chronic sinusitis is a common disease in otolaryngology head and neck surgery,but the pathogenesis is unknown.For a long time,we have used fungi,bacterial biofilms,superantigens,and low host immunity as the cause of chronic sinusitis.With the rapid development of molecular biology technology,especially the advancement of DNA sequencing technology,people’s research on human microbiome is deeper.We gradually realize the role of bacterial community in chronic sinusitis.This review will describe the role of bacteria in chronic sinusitis from three aspects:the composition of nasal bacterial community,the relationship between bacterial community and inflammatory phenotype,and the role between bacteria-host interaction.