FNA-Tg检测分化型甲状腺癌淋巴结转移的诊断效能及其影响因素

The diagnostic efficacy of FNA-Tg in detecting lymph node metastasis of differentiated thyroid cancer and its influencing factors

分化型甲状腺癌(DTC)患者易发生颈部淋巴结转移,影响患者的生存质量。准确诊断淋巴结转移可以为手术切除和清扫提供指导,改善患者预后。自首次利用细针穿刺洗脱液甲状腺球蛋白(FNA-Tg)诊断DTC患者淋巴结转移以来,已有大量的研究表明FNA-Tg对此具有良好的诊断效能。然而,由于检测的影响因素众多以及缺少统一的检测标准,研究结果差异较大。如何筛选合适的患者、建立统一的标准使FNA-Tg检测的效能最大化,是目前亟待解决的问题。本文将对FNA-Tg的诊断效能及其影响因素进行系统综述和分析,并对FNA-Tg的临床应用和研究方向进行展望。

Differentiated thyroid cancer(DTC)patients are prone to cervical lymph node metastasis,which affects patients′quality of life.Accurate diagnosis of lymph node metastasis can guide surgical resection and dissection,and improve patient′s prognosis.Since the first use of fine-needle aspiration washout thyroglobulin(FNA-Tg)to diagnose lymph node metastasis in DTC patients,a large number of studies have shown that FNA-Tg has a good diagnostic performance.However,due to the various influencing factors of detection and the lack of uniform detection standards,the results of studies very largely.How to screen suitable patients and establish uniform standards to maximize the efficiency of FNA-Tg detection is an urgent problem to be solved.This article will systematically review and analyze the diagnostic efficacy of FNA-Tg and its influencing factors,and explore the subsequent clinical application and research direction of FNA-Tg.