深圳市宝安区2016-2019年抗-HCV阳性就诊者HCV RNA检测结果分析

HCV RNA test results among anti-HCV positive patients in Bao’an district of Shenzhen, 2016-2019

目的了解2016-2019年深圳市宝安区医疗机构抗-丙型肝炎病毒(HCV)阳性就诊者HCV核糖核酸(RNA)检测情况,为评估深圳市宝安区HCV现症感染患者情况提供依据。方法收集深圳市宝安区8家公立综合性医院2016-2019年送检HCV RNA的抗-HCV阳性就诊者相关信息,利用检测者唯一性标识剔除重复检测数据条目,对HCV RNA阳性率进行统计分析,并运用2019年中深圳市宝安区常住人口数据进行标准化。结果共收集调查期间首次进行HCV RNA检测的抗-HCV阳性就诊者3671人,HCV RNA阳性1162人,阳性率31.65%,调整率26.51%[95%可信区间(CI):26.48%~26.55%]。其中男性阳性率35.36%,调整率29.90%(95%CI:29.85%~29.95%),女性阳性率26.50%,调整率21.68%(95%CI:21.63%~21.73%)。Logistic回归分析显示,性别、年龄、就诊类型和片区为抗-HCV阳性者HCV RNA阳性率的影响因素(P均<0.05)。男性抗-HCV阳性就诊者HCV RNA阳性的风险是女性的1.537倍。年龄每增加1岁,抗-HCV阳性就诊者HCV RNA阳性的风险增加3.1%。结论抗-HCV阳性就诊者HCV RNA阳性率分布存在性别和年龄差异。

Objective To understand the hepatitis C virus(HCV)RNA in blood among patients in Bao’an district of Shenzhen from 2016 to 2019,and to provide evidence for evaluation of hepatitis C infection.Methods We collected the information of HCV RNA test results among anti-HCV positive patients in 8 public general hospitals in Bao’an district from 2016 to 2019.Duplicate detection data items were deleted by using the unique identifier.We analyzed the positive rate of HCV RNA,which was standardized against the regional resident population reported in 2019.Results The data of 3671 anti-HCV positive patients were collected,who had their first HCV RNA test during the survey period,and 1162(31.65%)were HCV RNA positive(adjusted rate 26.51%,95%CI:26.48%-26.55%),among which 35.36%(adjusted rate 29.90%,95%CI:29.85%-29.95%)in males and 26.50%(adjusted rate 21.68%,95%CI:21.63%-21.73%)in females.Logistic regression analysis showed that gender,age,types of clinic departments and areas were the influencing factors of HCV RNA infection(P<0.05).The risk of HCV RNA positive in male anti-HCV positive patients was 1.537 times as high as that in females.The risk of HCV RNA positive of anti-HCV positive patients increased by 3.1%for every additional year.Conclusion There were gender and age differences in the distribution of HCV RNA positive rate among anti-HCV positive patients.