摘要
目的观察血清Ca2+、ALP及肿瘤标志物在肺癌骨转移预测价值。方法选取236例中晚期肺癌病例(本院2016年1月至2018年12月收治)作为研究对象,所有病例均于确诊时行血清Ca2+、ALP及肿瘤标志物检测进行骨转移预测。统计所有病例1年时病理检查肺癌细胞骨转移情况,分析非骨转移与骨转移病例、不同骨转移soloway程度分级病例的血清Ca2+、ALP及肿瘤标志物水平差异,分析其在肺癌骨转移中的预测效能。结果 236例肺癌中晚期病例中,158例(66.95%)未发生骨转移,78例(33.05%)发生骨转移,其中骨转移M1、M2、M3分别39例(16.53%)、21例(8.90%)、18例(7.62%)。非骨转移病例的Ca2+、ALP及肿瘤标志物均低于骨转移病例(P<0.05)。随着骨转移soloway程度分级提升,Ca2+、ALP及肿瘤标志物均提升(P<0.05)。Ca2+、ALP及肿瘤标志物联合的预测敏感性(90.17%)、预测特异性(92.18%)、预测准确率(94.18%)均高于各单项指标的预测敏感性(73.15%~86.15%)、预测特异性(73.86%~88.91%)、预测准确率(73.14%~88.12%)(P<0.05)。结论血清Ca2+、ALP及肿瘤标志物均在肺癌骨转移预测中具有重要的价值,且联合应用可进一步提升预测敏感性、预测特异性和预测准确性。
Objective To observe the predictive value of serum Ca2+, ALP and tumor markers in bone metastasis of lung cancer. Methods 236 cases of middle-late stage lung cancer in our hospital from January 2016 to December 2018 were selected as the research object, and all cases were confirmed in their serum Ca2+, ALP and bone metastases tumor markers to predict bone metastases. The situation of bone metastases from lung cancer was analyzed during 1 year follow-up, in order to analyze the differences in serum Ca2+, ALP and tumor markers between bone metastases patients and non bone metastases patients. Results Among the 236 patients with middle and advanced lung cancer, 158(66.95%) had no bone metastasis and 78(33.05%) had bone metastasis, among which 39(16.53%) had bone metastasis M1, M2, M3, 21(8.90%), and 18(7.62%) had non-bone metastasis. The levels of Ca2+, ALP and tumor markers were lower in non bone metastases patients than those in bone metastasis patients(P<0.05), and they increased with the soloway grading of bone metastases. The combined prediction sensitivity(90.17%), specificity(92.18%) and prediction accuracy(94.18%) were higher than that of each single indicator’s sensitivity(73.15%~86.15%), specificity(73.86%~88.91%) and accuracy(73.14%~88.12%)(P<0.05). Conclusion Serum Ca2+, ALP and tumor markers have important value in the prediction of bone metastasis of lung cancer, and the combined application can further improve the prediction sensitivity, specificity and accuracy.
作者
张莹
张竞文
杨杨
ZHANG Ying;ZHANG Jing-wen;YANG Yang(Xuzhou First People's Hospital,Xuzhou,Jiangsu 221000,China)
出处
《临床肺科杂志》
2020年第8期1218-1222,共5页
Journal of Clinical Pulmonary Medicine