替罗非班桥接常规抗血小板治疗早期PWI-DWI不匹配脑梗死的疗效评价

Therapeutic efficacy of tirofiban and routine antiplatelet therapy in early PWI-DWI mismatched cerebral infarction

目的观察替罗非班桥接常规抗血小板治疗对早期磁共振灌注成像-弥散成像(PWI-DWI)不匹配脑梗死的疗效。方法60例PWI-DWI不匹配大脑中动脉供血区脑梗死患者随机采用阿司匹林肠溶片和氢氯吡格雷片(常规组)或静脉泵入负荷罗非班桥接常规抗血小板(观察组)治疗,比较两组脑梗死改善、进展性脑卒中发生率和临床疗效。结果观察组NIHSS、ADL、mRS评分及疗效优于常规组(P<0.05),进展性脑梗死发生率低于对照组(P<0.05)。结论替罗非班桥接常规抗血小板治疗早期PWI-DWI不匹配脑梗死可遏制进展性脑梗死发生,改善神经功能和预后。

Objective To observe the clinical efficacy of tirofiban and routine antiplatelet therapy(RAPT)in early PWIDWI mismatched cerebral infarction(CI).Methods Sixty patients with early PWI-DWI mismatched CI due to middle cerebral artery occlusion were randomly treated with aspirin and clopidogrel(conventional group)or tirofiban and RAPT(observation group).CI improvement,progressive CI,and clinical efficacy were compared between two groups.Results Compared with conventional group,NIHSS,activities of daily living(ADL),modified rankin scale(mRS),and clinical efficacy were higher(P<0.05),while progressive CI was lower(P<0.05)in observation group.Conclusion Combined use of tirofiban and RAPT can suppress progressive CI and improve neurological function and prognosis in patients with early PWIDWI mismatched CI.