慢性萎缩性胃炎患者血清胃蛋白酶原、胃泌素-17水平检测及临床意义

Serum levels and clinical significance of pepsinogen and gastrin-17 in chronic atrophic gastritis

目的探讨慢性萎缩性胃炎(CAG)患者血清胃蛋白酶原(PG)和胃泌素-17(G-17)水平及临床意义。方法ELISA检测90例CAG患者(胃窦萎缩48例、胃体萎缩22例、全胃多灶萎缩20例)和85例非萎缩性胃炎患者血清PGⅠ、PGⅡ、G-17水平。结果与对照组比较,观察组PGⅠ、PGⅡ、PGⅠ/PGⅡ比值明显降低(P<0.01或0.05),而G-17水平明显升高(P<0.01)。胃体萎缩组PGⅠ、PGⅡ、PGⅠ/PGⅡ比值均低于全胃多灶萎缩、胃窦萎缩组(P<0.05),而G-17水平升高(P<0.05)。结论联合检测血清PGⅠ、G-17水平及PGⅠ/PGⅡ比值有助于判断CAG患者胃黏膜萎缩部位和程度。

Objective To study serum levels and clinical significance of pepsinogen(PG)and gastrin-17(G-17)in chronic atrophic gastritis(CAG).Methods Serum levels of PGⅠ,PGⅡand G-17 were determined by ELISA in 90 CAG cases(antral atrophy,n=48;gastric body atrophy,n=22;multifocal atrophy,n=20)and 85 non-CAG cases.Results Compared with non-CAG group,PGⅠand PGⅡlevels and PGⅠ/P GⅡratio decreased(P<0.01 or 0.05),while G-17 level increased in CAG group(P<0.01).PGⅠand PGⅡlevels and PGⅠ/P GⅡratio were lower but G-17 level was higher in gastric atrophy group than in antral and multifocal atrophy groups(P<0.05).Conclusion Combined detection of serum PGI and G-17 levels and PGⅠ/P GⅡratio could be helpful to evaluate the location and degree of gastric mucosa atrophy in CAG patients.