摘要
目的观察还少丹治疗脾肾亏虚型轻、中度阿尔茨海默病(AD)临床疗效。方法将84例脾肾亏虚型轻、中度AD患者按照随机数字表法分为2组。治疗组42例予还少丹治疗,对照组42例予盐酸多奈哌齐治疗。2组均治疗24周,观察2组治疗前后简易精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、阿尔茨海默病评定量表-认知分量表(ADAS-cog)评分、日常生活活动能力量表(ADL)评分、临床痴呆分级量表(CDR)评分及痴呆证候分型量表(SDSD)评分。结果治疗后2组MMSE评分、MoCA评分均较本组治疗前升高(P <0. 05),ADAS-cog评分、ADL评分、CDR评分及SDSD评分均较本组治疗前降低(P <0. 05)。2组治疗后MMSE评分、MoCA评分、ADAS-cog评分、ADL评分、CDR评分组间比较差异均无统计学意义(P>0. 05)。治疗后治疗组SDSD评分低于对照组(P <0. 05)。结论还少丹可改善脾肾亏虚型轻、中度AD患者的认知功能及日常生活能力,且在改善中医证候方面优于盐酸多奈哌齐,适于推广应用。
Objective To observe the effect of Huanshaodan in the treatment of mild to moderate alzheimer’s disease( AD) of spleen and kidney deficiency type. Methods 84 cases of mild to moderate AD of spleen and kidney deficiency type were randomly divided into two groups according to the random number table method. 42 cases in treatment group were treated by Huanshaoda. 42 cases in control group were treated by donepezil hydrochloride.Both groups were treated for 24 weeks. The scores of mini-mental state examination( MMSE),montreal cognitive assessment( MoCA),Alzheimer’s disease rating scale cognitive subscale( ADAS-cog),form of activity of daily life( ADL),clinical dementia rating scale( CDR) and dementia syndrome classification scale( SDSD) were observed before and after treatment. Results After treatment,MMSE score and MOCA score of the two groups were higher than those in the group before treatment( P < 0. 05),ADAS-cog score,ADL score,CDR score and SDSD score were lower than those in the group before treatment( P < 0. 05). There was no significant difference in MMSE score,MoCA score,ADAS-cog score,ADL score and CDR score between the two groups after treatment( P > 0. 05). After treatment,the SDSD score of the treatment group was lower than that of the control group( P < 0. 05). Conclusion Huanshaodan can improve cognitive function and activities of daily living of mild to moderate AD patients with spleen and kidney deficiency type,and it is better than donepezil hydrochloride in improving TCM syndromes,and is also suitable for popularization and application.
作者
杨芳
杨雪萍
徐月
邱雪梅
陈卫银
李炜弘
YANG Fang;YANG Xueping;XU Yue(Department of Neurology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610072)
出处
《河北中医》
2020年第4期538-542,共5页
Hebei Journal of Traditional Chinese Medicine
基金
国家重点研发计划项目(编号:2017YFC1703304)
成都中医药大学校基金项目(编号:ZRQN1749)。
关键词
阿尔茨海默病
中药疗法
Alzheimer’s disease
Chinese medicine therapy