雷公藤多甙联合白芍总苷治疗干燥综合征的临床效果及对抗心磷脂抗体、类风湿因子的影响

Clinical effect of tripterygium glycosides combined with total glucosides of paeony in the treatment of Sjogren’s syndrome and its influences on anticardiolipin antibody and rheumatoid factor

目的探讨雷公藤多甙联合白芍总苷治疗干燥综合征的临床效果及对抗心磷脂抗体(ACL)、类风湿因子(RF)的影响。方法选择2016年9月至2019年9月的76例干燥综合征患者,采用随机数字表法将其分为对照组和观察组,各38例。对照组采用雷公藤多甙治疗,观察组采用雷公藤多甙联合白芍总苷治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的ESR、CRP水平显著低于对照组(P<0.05)。治疗后,观察组的ACL、RF水平低于对照组(P<0.05)。结论雷公藤多甙联合白芍总苷治疗干燥综合征可提高临床效果,进一步降低患者ESR、CRP、ACL及RF水平,值得推广。

Objective To investigate the clinical effect of tripterygium glycosides combined with total glucosides of paeony in the treatment of Sj?gren’s syndrome and its influences on anticardiolipin antibody(ACL)and rheumatoid factor(RF).Methods A total of 76 patients with Sj?gren’s syndrome from September 2016 to September 2019 were selected and divided into two control group and observation group according to random number table method,with 38 cases in each group.The control group was treated with tripterygium glycosides,and the observation group was treated with tripterygium glycosides combined with total glucosides of paeony.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the ESR and CRP levels of the observation group were significantly lower than those of the control group(P<0.05).After treatment,the ACL and RF levels of the observation group were lower than those of the control group(P<0.05).Conclusion Tripterygium glycosides combined with total glucosides of paeony in the treatment of Sj?gren’s syndrome can improve the clinical effect and further reduce the ESR,CRP,ACL and RF levels of patients,which is worthy of promotion.