姜黄素药理作用及机制研究进展

Research progress of curcumin pharmacological effect and mechanism

姜黄素是从中药姜黄中提取的一种植物多酚,也是姜黄发挥药理作用最重要的活性成分。现代药理学研究显示,姜黄素有抗肿瘤、抗炎、抗氧化、抗纤维化及心肌保护等药理作用。本文综合近些年文献,阐述姜黄素的抗肿瘤机制(包括抑制肿瘤细胞血管生成、抑制肿瘤细胞增殖、阻遏细胞周期、诱导细胞凋亡、抑制肿瘤细胞迁移和侵袭等)及姜黄素发挥抗炎、抗氧化、抗纤维化、心肌保护等作用治疗多种肿瘤、非肿瘤疾病,以期为姜黄素开发利用研究提供参考。

Curcumin is a plant polyphenol extracted from turmeric of traditional Chinese medicine,and it is also the most important active component of turmeric to play a pharmacological role.Modern pharmacological studies have shown that curcumin has anti-tumor,anti-inflammatory,anti-oxidation,anti-fibrosis and myocardial protection and other pharmacological effects.This paper synthesizes the literature of recent years to elaborate the anti-tumor mechanism of curcumin(including inhibiting tumor cell angiogenesis,inhibiting tumor cell proliferation,repressing cell cycle,inducing apoptosis,inhibiting tumor cell migration and invasion,etc.)and the treatment of various tumor,non-tumor diseases by curcumin by exerting its anti-inflammatory,anti-oxidation,anti-fibrotic,myocardial protection,etc.,in order to provide reference for the development and utilization of curcumin.