地西他滨治疗老年急性髓系白血病41例

Decitabine in the Treatment of 41 Cases of Acute Myeloid Leukemia in the Elderly

目的研究地西他滨治疗老年急性髓系白血病41例的临床效果。方法选取本院收治的老年急性髓系白血病患者82例,根据不同治疗方案将其分为两组各41例。对照组采用常规化疗治疗,观察在此基础上采用地西他滨治疗,比较两组的治疗效果和不良反应发生情况。结果观察组治疗有效率(60.98%)明显高于对照组(39.02%)(P <0.05);两组的肝功能损害、脱发、腹泻发生率对比无显著差异(P> 0.05);观察组血小板减少发生率(7.32%)明显低于对照组(26.83%)(P <0.05),恶心呕吐、肺部感染、发热发生率(39.02%、43.90%、36.59%)明显高于对照组(14.63%、17.07%、17.07%)(P <0.05)。结论地西他滨治疗老年急性髓系白血病能够有效减轻患者临床症状,促进血常规、骨髓象恢复,提升治疗效果,但仍需严密监测不良反应,保障治疗安全性。

Objective To study the clinical effect of decitabine in the treatment of 41 elderly patients with acute myeloid leukemia. Methods Eightytwo patients with acute myeloid leukemia admitted to our hospital were enrolled in this study. They were divided into two groups according to different treatment options. The control group was treated with conventional chemotherapy. On the basis of this treatment, decitabine was used to compare the therapeutic effects and adverse reactions of the two groups. Results The effective rate of treatment group(60.98%) was significantly higher than that of the control group(39.02%)(P<0.05). There was no significant difference in the incidence of liver damage, alopecia and diarrhea between the two groups(P>0.05). The incidence of thrombocytopenia(7.32%) was significantly lower than that of the control group(26.83%)(P<0.05). The incidence of nausea and vomiting, lung infection, and fever(39.02%, 43.90%, 36.59%) was significantly higher than that of the control group(14.63%, 17.07%, 17.07%)(P<0.05). Conclusion Decitabine can effectively relieve the clinical symptoms of patients with acute myeloid leukemia, promote the recovery of blood routine and bone marrow, and improve the therapeutic effect. However, it is still necessary to closely monitor adverse reactions and ensure the safety of treatment.