替格瑞洛与氯吡格雷治疗冠心病不稳定心绞痛的临床疗效对比

Comparison of Clinical Efficacy between Tigrew and Clopidogrel in the Treatment of Unstable Angina Pectoris of Coronary Heart Disease

目的探究冠心病不稳定心绞痛患者采用替格瑞洛与氯吡格雷的治疗效果对比。方法于2017年4月至2019年5月这一期间,随机选取本院96例冠心病不稳定心绞痛,并按照双盲法分为2组,对比组氯吡格雷治疗,实验组实施替格瑞洛治疗,并对两组患者的治疗效果、心绞痛发作持续时间、发作频率、hs-CRP、IL-6与重大不良心血管事件发生率进行对比。结果实验组治疗有效率91.67%,与对比组的75%比较经分析有统计学意义(P<0.05);两组治疗90 d后心绞痛发作持续时间与发作频率均比治疗前低,并且实验组治疗后的降低水平比对比组更高(P<0.05);两组患者治疗后IL-6与hs-CRP水平均比治疗前低,并且治疗后两组患者IL-6与hs-CRP水平的降低程度比对比组高(P<0.05);实验组心血管不良事件发生率8.33%,与对比组的18.75%相比较没有统计学意义(P>0.05)。结论与氯吡格雷相比,冠心病不稳定心绞痛患者采用替格瑞洛的治疗效果更好,可减少心绞痛发作持续时间与发作频率,改善炎性因子水平,减少不良事件的出现。

Objective To explore the therapeutic effects of tigrew and clopidogrel in patients with unstable angina pectoris of coronary heart disease. Methods From April 2017 to May 2019, 96 patients with unstable angina pectoris of coronary heart disease in our hospital were randomly selected and divided into two groups according to double-blind method. The control group was treated with clopidogrel and the experimental group was treated with tigrew. The therapeutic effect, duration of angina pectoris attack, attack frequency, hs-CRP, IL-6 and incidence rate of major unconscionable vascular events were compared between the two groups. Results The effective rate of treatment in the experimental group was 91.67%, which was statistically significant compared with 75% in the control group(P<0.05). After 90 days of treatment, the duration and frequency of angina pectoris attacks in both groups are lower than before treatment, and the reduction level after treatment in the experimental group is higher than that in the control group(P<0.05). The levels of IL-6 and hs-CRP in the two groups after treatment were lower than before treatment, and the level of IL-6 and hs-CRP in the two groups after treatment was lower than that in the control group(P<0.05). The incidence of cardiovascular adverse events in the experimental group was 8.33%, which was not statistically significant compared with 18.75% in the control group(P>0.05). Conclusion Compared with clopidogrel, tigrew is more effective in the treatment of unstable angina pectoris patients with coronary heart disease. It can reduce the duration and frequency of angina pectoris attacks, improve the level of inflammatory factors, and reduce the occurrence of adverse events.